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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

The structure of the alcohol and anesthetic binding site in the strychnine-sensitive glycine receptor

Lobo, Ingrid Ann 28 August 2008 (has links)
Not available / text
12

Subcellular distribution and binding characterization of the peripheral benzodiazepine receptor in the rat liver

Duerson, Kevin Collin, 1958- January 1988 (has links)
The peripheral benzodiazepine receptor (PBZ) population in the rat liver has been kinetically and pharmacologically characterized. These data revealed a receptor with a dissociation constant (Kd) of 5.67 nM and a receptor density of 758 fmoles/ mg protein in a crude membrane preparation. Subcellular distribution studies demonstrated that PBZs were detected in highly purified nuclear, mitochondrial and microsomal fractions. Porphyrins were shown to interact at the PBZ with protoporphyrin IX and hemin having the highest affinity. Preliminary studies on the subnuclear distribution of PBZs are reported. In summary, the study has (1) characterized liver PBZs, (2) shown the subcellular distribution of these receptors and (3) pharmacologically characterized nuclear, mitochondrial and microsomal PBZs in the liver.
13

Characterization of the human secretin receptor gene

方士銘, Fong, Shi-ming. January 1998 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
14

The structure of the alcohol and anesthetic binding site in the strychnine-sensitive glycine receptor

Lobo, Ingrid Ann, Harris, R. Adron, January 2004 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2004. / Supervisor: R. Adron Harris. Vita. Includes bibliographical references.
15

A study on the cardiac k-opioid receptors : function, binding properties & signal transduction /

Tai, Kwok-keung. January 1993 (has links)
Thesis (Ph. D.)--University of Hong Kong, 1993.
16

The distribution and metabolism of acetylcholine receptors on skeletal muscle fibers during development of the neuromuscular junction

Burden, Steven Jay. January 1977 (has links)
Thesis--Wisconsin. / Vita. Includes bibliographical references (leaves 132-142).
17

Delta Opioid Receptor (δOR) Trafficking in the Central Nervous System

Lucido, Anna Lisa January 2005 (has links)
No description available.
18

Functional interaction between sigma and N-methyl-D-aspartate receptors in the rat hippocampus

Monnet, François P. January 1992 (has links)
Note:
19

The Autoradiographic Localization of Estrogen Binding Sites in Human Mammary Lesions

Buell, Richard H. January 1984 (has links)
No description available.
20

Molecular interaction studies of mouse secretin and angiotensin II receptors and their potential implications in water homeostasis

Ng, Yuen-lam, Stephanie, 吳宛霖 January 2014 (has links)
Osmoregulation is critical to life and is tightly regulated by integrated physiological and behavioral responses to maintain the osmolality of body fluid. In particular, this involves recovery from dehydration both at the intracellular and extracellular levels. To achieve appropriate body fluid balance, three major hormones namely secretin (SCT), angiotensin II (ANGII) and vasopressin (VP) are responsible. Of note, SCT and ANGII share overlapping physiological roles including similar expression pattern within the brain, dipsogenic actions and activation of VP expression and/or release in mice. However, it remains unclear how their receptor pathways may cross-interact to aid osmoregulation. In recent years, G protein-coupled receptor (GPCR) oligomerization has been implicated to play roles in regulating processes such as expression, pharmacological diversity, signal transduction and internalization. Though not as extensively studied, class B GPCRs are also gaining merit in their oligomerization abilities, within which the wealth of available information is focused on SCT receptor (SCTR) homomers and heteromers. Moreover, there is also evidence indicating the ability for ANGII receptors to oligomerize. On the basis of this information, this project predominantly aims to explore the molecular association between SCTR and ANGII receptors via in vitro experiments and provide insights into its physiological relevance. In this study, bioluminescence resonance energy transfer (BRET) assays revealed SCTR and ANGII type 1a receptor (AT1aR) to form hetero-complexes. This oligomerization event was found by BRET competition to be contributed predominantly by transmembrane (TM) domain regions 2 and 4 in SCTR, and TM1 and TM4 in AT1aR. Within which, combinational use of mutant TM peptides and SCTR chimeras revealed the importance of lipid-exposed residues, particularly Leu204 and Ser205 in SCTR TM2 as key contact points for formation of the SCTR/AT1aR complex. Morphologically, the heteromers were visualized by confocal FRET imaging at the cell surface and found have a role in modulating AT1aR trafficking. It was also found that the SCTR/AT1aR complex affected Gαs signaling specifically, reducing maximal response values by 24.3 ± 2.8 % compared to CHO-K1 cells transfected with only SCTR. While, this negative effect could be abolished by co-application of SCT and ANGII peptides, use of constitutively active AT1aR mutants or disruption of the hetero-complex using SCTR mutants. Taken together, the SCTR/AT1aR complex was proposed to impose conformational restraints on the SCTR that could be overcome upon activation of the AT1aR. Physiologically, hyperosmolality isovolemic induced drinking could be attenuated by central administration of TM peptides and the protein kinase A pathway blocker H-89, indicating receptor oligomerization to have a role in neural osmoregulation via a Gαs dependent pathway. This study presents novel findings regarding the receptor oligomerization of SCTR and AT1aR, which may be the molecular basis to the overlapping roles of SCT and ANGII in water homeostasis. / published_or_final_version / Biological Sciences / Doctoral / Doctor of Philosophy

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