Doctor en Ingeniería Eléctrica / In this thesis an uncertainty weighting scheme for deep neural network-hidden Markov model (DNN-HMM) based automatic speech recognition (ASR) is proposed to increase discriminability in the decoding process. To this end, the DNN pseudo-log-likelihoods are weighted according to the uncertainty variance assigned to the acoustic observation. The results presented here suggest that substantial reduction in word error rate (WER) is achieved with clean training. Moreover, modelling the uncertainty propagation through the DNN is not required and no approximations for non linear activation functions are made. The presented method can be applied to any network topology that delivers log likelihood-like scores. It can be combined with any noise removal technique and adds a minimal computational cost. This technique was exhaustively evaluated and combined with uncertainty-propagation-based schemes for computing the pseudo-log-likelihoods and uncertainty variance at the DNN output. Two proposed methods optimized the parameters of the weighting function by leveraging the grid search either on a development database representing the given task or on each utterance based on discrimination metrics. Experiments with Aurora-4 task showed that, with clean training, the proposed weighting scheme can reduce WER by a maximum of 21% compared with a baseline system with spectral subtraction and uncertainty propagation using the unscented transform. Additionally, it is proposed to replace the classical black box integration of automatic speech recognition technology in human-robot interaction (HRI) applications with the incorporation of the HRI environment representation and modeling, and the robot and user states and contexts. Accordingly, this thesis focuses on the environment representation and modeling by training a DNN-HMM based automatic speech recognition engine combining clean utterances with the acoustic channel responses and noise that were obtained from an HRI testbed built with a PR2 mobile manipulation robot. This method avoids recording a training database in all the possible acoustic environments given an HRI scenario. In the generated testbed, the resulting ASR engine provided a WER that is at least 26% and 38% lower than publicly available speech recognition application programming interfaces (APIs) with the loudspeaker and human speakers testing databases, respectively, with a limited amount of training data. This thesis demonstrates that even state-of-the-art DNN-HMM based speech recognizers can benefit by combining systems for which the acoustic models have been trained using different feature sets. In this context, the complementarity of DNN-HMM based ASR systems trained with the same data set but with different signal representations is discussed. DNN fusion methods based on flat-weight combination, the minimization of mutual information and the maximization of discrimination metrics were proposed and tested. Schemes that consider the combination of ASR systems with lattice combination and minimum Bayes risk decoding were also evaluated and combined with DNN fusion techniques. The experimental results were obtained using a publicly-available naturally-recorded highly reverberant speech data. Significant improvements in WER were observed by combining DNN-HMM based ASR systems with different feature sets, obtaining relative improvements of 10% with two classifiers and 18% with four classifiers, without any tuning or a priori information of the ASR accuracy.