Redhead duck (Aythya americana) nesting and habitat change was studied in Knudson Marsh, Utah, in 1974 and 1975, and compared with earlier studies from 1950 and 1955 on the same marsh. Water condibons in 1975 were found to be similar to those in 1950, both years of favorable habitat, yet there was a decline in numbers of redheads from 500 pair s in 1950 to 50 pairs in 1975. The number of nests found also declined from 151 in 1950 to 49 in 1975. Water conditions were poor in 1955 and slightly more favorable in 1974, but there was a decline from 95 pairs and 49 nests in 1955 to 50 pairs and 23 nests in 1974. Success of active nests was greater in the present study than in 1950, but hatching success in successful nests was greater in 1950. No appreciable change in the vegetational composition of the marsh was detected between 1950 and the present study.

BRAF(V600E), the most commonly mutated oncogene in melanoma, is found in about half of patients. By hyperactivating the MAPK pathway, this mutation promotes cell growth and proliferation. Melanocytic BRAF(V600E) alone, however, is insufficient to cause melanoma and rather promotes the development of benign nevi (moles). The goal of our initial studies was to better understand how genetic and environmental risk factors interact with the BRAF(V600E) oncogene to induce melanoma. The two most prominent risk factors for melanoma development are exposure to ultraviolet (UV) radiation and pale skin pigmentation; particularly in the case of individuals with the “redhead” phenotype, who carry inactivating mutations in the MC1R G-protein coupled receptor. It has commonly been thought that redheads are at highest risk for melanoma development due to poor protection from genotoxic UV radiation from the sun. Using a melanocyte-specific, inducible Braf(V600E) mouse model, we have shown that an inactivating mutation in Mc1r which causes a redhead phenotype in mice, confers a significant UV-independent elevation in melanoma risk, relative to black and albino animals. The mechanism of accelerated UV-independent oncogenesis was found to be dependent on the synthesis of the red/yellow pheomelanin pigment. While these experiments were on-going, a novel small molecule inhibitor of the BRAF(V600E) oncogene, vemurafenib, began showing promising results in clinical trials. The observation that half of patients were experiencing significant tumor regression was unprecedented, but was soon followed by vemurafenib-resistant disease progression. Based on the fact that acquired drug resistance is a major obstacle to good therapeutic outcomes, we began investigating mechanisms of BRAF inhibitor resistance. A panel of BRAF(V600E) human melanoma cell lines that were initially sensitive to PLX4720 (a pre-clinical analog of vemurafenib), were chronically treated with the oncogenic BRAF inhibitor until resistance developed. These paired resistant and sensitive cell lines were characterized in terms of drug sensitivity and activation of cell signaling pathways. Multiple different patterns of drug resistance were found. The diversity of resistance mechanisms in these studies agrees with the diversity which others have found in the literature, suggesting that melanoma cells may be uniquely adaptable to circumventing BRAF(V600E) oncogene addiction.

Redhead duck (Aythya americana) nesting and habitat change was studied in Knudson Marsh, Utah, in 1974 and 1975, and compared with earlier studies from 1950 and 1955 on the same marsh. Water conditions in 1975 were found to be similar to those in 1950, both years of favorable habitat, yet there was a decline in numbers of redheads from 500 pairs in 1950 to 50 pairs in 1975. The number of nests found also declined from 151 in 1950 to 49 in 1975. Water conditions were poor in 1955 and slightly more favorable in 1974, but there was a decline from 95 pairs and 49 nests in 1955 to 50 pairs and 23 nests in 1974. Success of active nests was greater in the present study than in 1950, but hatching success in successful nests was greater in 1950. No appreciable change in the vegetational composition of the marsh was detected between 1950 and the present study.

Though the remnants of a stereotype created over two millennia ago still thrive in American popular culture today, redheaded women are enjoying a more positive role in society than they have ever seen before. Women in Red explores the experience of the redheaded woman in America today by examining how the stereotypes have affected a small group of them, how these women relate to the stereotypes, and why, given the verisimilitude of the stereotype, a non-redheaded woman would embrace such an identity with the simple act of dying her hair red. This is the story behind the experience that is Women in Red.