It can be observed that the anti-normative behaviors occur more frequently in Computer-Mediated-Communication than in face-to-face communication. Internet often let people feel less restraint to use rude or threatening language, leashing harsh criticisms, venting anger or hatred. Thus, the issues surrounding ¡§Toxic Disinhibition¡¨ have attracted more and more concern from society and academia. Our empirical study tries to get the whole picture and proposed a more comprehensive model integrating diverse factors and involving the synthesis of different viewpoints. Accordingly, this paper proceeds to examine and integrate the two important aspects, (1) Internet attributes in which reduced social cue, social presence, controllability, and the fluidity of the identity and (2) psychological state, especially theories of deindividuation.Moreover, different from most prior researches, we consider deindividuation as an important mediating role, not just an antecedent of toxic disinhibition. An empirical survey methodology is applied to test the research model and six hypotheses are developed in this study, and then we use PLS to analyze it. Our empirical results showed that the essential mediating role of deindividuation, also confirming the highly significant with toxic disinhibition. Moreover, we identify major factors that may affect deindividuation. We find that except for reduced social cue, reduced social presence, controllability and fluidity of identity also has significant impact on deindividuation, and then cause toxic disinhibition. In sum, unlike much prior research that has focused on only a limited aspect of toxic disinhibition, we take integrated view and proposed a more comprehensive model therefore be useful to a better understanding of the nature of toxic disinhibition. And this study provides some suggestions for the online disinhibition research.