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The population growth in many urban cities and its activities in developing countries have resulted in an increased solid waste generation rate and waste management has become a global environmental issue. Routing of solid waste collection vehicles in developing countries like Pakistan poses a challenging task. In the process of solid waste management, collection and transportation play a leading role in waste collection and disposal, in which collection activities contributed the most to total cost for solid waste collection activities. Therefore, this study describes an attempt to design and develop an appropriate collection, transportation and disposal plan for the twin cities of Pakistan by using Geographic Information System (GIS) and Remote Sensing (RS) techniques to determine the minimum cost/distance/time efficient collection paths for the transportation of the solid wastes to the landfill sites. In addition to this, identification of solid waste disposal sites and appropriately managing them is a challenging task to many developing countries and Pakistan is no exception to that. The existing landfill sites for the twin cities are not technically viable and environmentally acceptable and are thus damaging to the environment due to their location and the type of waste dumped. Therefore, the second aim of our study was to find out the suitable landfill sites for the twin cities and the study employed Multi-Criteria Evaluation (MCE) methods to combine necessary factors considered for landfill site selection for the twin cities. Hence, our present study has proved that GIS is a tool that can be used in integration with other techniques such as MCE for a identifying new landfill sites and it can help decision makers deal with real-world developmental and management issues. Finally, the study has developed a Wed-Based Decision Support System (DSS) via Application Programming Interface (API) which will help decision-makers to search for cost-effective alternatives and it can be operated by people who don’t have knowledge of GIS. The proposed study can be used as a decision support tool by the municipalities of the twin cities for efficient management and transportation of solid wastes to landfill sites, managing work schedules for workers, etc.