When Global Regional Economics came into being one after another, the connection between industry development and specialized division accelerates the establishment of regional operational headquarters by Multinational Corporations. As for cities, the key factors in attracting enterprises for setting up Operation Center are the environment which suit with development. The literatures and data indicated that the city with strong competitiveness may have more significant industry clusters; besides, the how does a city connect with global market will become the crucial element in city development. All the time, the overall development of Taiwan has been influence by the political situation between Taiwan Strait, so as soon as the relationship between Taiwan Strait been improved, the chances of interflowing between Taiwan Strait will grow in number. Under this situation, how Kaohsiung city builds up the mechanism of industries division and corporation become an important issue when it comes to setting up the regional operation center. From the case study of Hong Kong, Singapore and Shanghai, I sums up with location condition, government policies and human resource as the weaker part for Kaohsiung as an operation center. Also, from the analysis of the related data, geographic superiority, traffic condition, the perfection of infrastruction, the cooperation of supporting industries, government policies and human resource should be put into consideration when a operation center choosing its operation location; among of them, government policies is the most powerful element. According to this founding, the executive managers of six golden industries for Kaohsiung are selected as the interviewees. Taking production factors, requirement conditions, support condition and government policies as the interviewing outline, and with the help of ATLAS.ti, forty-one indicators of advancing regional operation headquarter for Kaohsiung are resulted. According to the data, interviewees believe that Kaohsiung city should work harder to advance the regional operation headquarter, including the insufficient of human resource, irrelevancy of enactment and lack of related industries etc.. Kaohsiung city now is in the phase of transforming and her out value is led by manufacturing industry. However, with the advantage of manufacturing and two ports, the interviewees still believed on the Kaohsiung city once city government can combine these advantages with government policies and human resource. Most importantly, the leading sections should jump out of the box of bureaucracy and fully use the resources of industry, scholar and government; furthermore, they should improve the government efficiency by horizontal integration and develop the module of partnership, with these improvement and development, Kaohsiung will get closer to the regional operation headquarter.