Ensemble simulations of smoke aerosol radiative effects with a regional climate model in the Amazon has been conducted to investigate the radiative effects of aerosols on clouds, rainfall, and circulation from dry to wet season. The results of the ensemble simulations suggest that the radiative effect of the smoke aerosols can reduce daytime surface radiative and sensible fluxes, the depth and instability of the planetary boundary layer (PBL), consequently the clouds in the lower troposphere in early afternoon in the smoke center, where the aerosols optical depth, AOD, exceeds 0.3. The aerosol radiative forcing also appears to weaken moisture transport into the smoke center and increase moisture transport and cloudiness in the region upwind to the smoke center, namely, the northern Amazon. Anomalous wind convergence over the equatorial western Amazon occurs to compensate the anomalous wind divergence in the southern Amazon, leading to an increase of both clouds and rainfall in that region. The increased atmospheric thermodynamic stability in Southern Amazonia also appears to block synoptic cyclonic activities propagated from extratropical South America, leading to an increased synoptic cyclonic activities and rainfall in southern Brazil, Paraguay and northern Argentina. Evidently, the dynamic response of the monsoon circulation plays a major role in determining the pattern of rainfall change induced by the radiative effect of the aerosols.