<p dir="ltr">This thesis revisits self-organizing maps (SOM) and explores their applications as both a clustering and feature learning method, establishing SOM as a powerful tool for analyzing complex biological and temporal datasets. The first study integrates evolutionary information with co-fractionation mass spectrometry data to create enhanced benchmarks for protein complex predictions. The second study applies SOM to investigate the intricate relationships between mRNA and protein expression levels during cotton fiber development. By clustering mRNA-protein pairs based on their time-course profiles, SOM captures distinct, non-linear patterns that extend beyond traditional linear correlation methods, offering new insights into gene expression and protein production dynamics. In the third study, SOM is integrated with a generative model, the Variational Autoencoder (VAE), and a Long Short-Term Memory (LSTM) network to tackle challenges in time-series clustering. This framework combines VAE for learning latent representations, LSTM for capturing temporal dependencies, and SOM for clustering, achieving superior performance in modeling complex temporal patterns. Through these studies, this thesis redefines SOM as a versatile and effective tool for uncovering complex patterns in biological and temporal datasets, demonstrating its relevance and potential in modern data analysis.</p>

Hierdie studie is 'n kwalitatiewe ekosistemiese ondersoek van die fenomeen Chroniese Moegheidsindroom (CMS) . Die paradigmaverskuiwing vanaf die Cartesiaans-Newtoniaanse epistemologie na die kubernetiese epistemologie, het 'n aantal belangrike implikasies vir die bestudering en konseptualisering van CMS, soos uiteengesit in hierdie studie. 'n Bespreking van die konseptualisering en behandeling van CMS vanuit die tradisionele, reduksionistiese navorsing word verskaf. Die aannames van twee-orde kubernetika en sosiale konstruksionisme, is bespreek en toegepas op die beskrywing van twee sisteme waarin CMS voorkom. Die navorsingsmetodologie van die studie is gegenereer op grand van die genoemde teoretiese aannames. Die implikasies van die toepassing van die ekosistemiese epistemologie vir die konseptualisering van CMS word uitgewys. Die herkonseptualisering van CMS as 'n transisieproses word bespreek en riglyne vir verdere navorsing en psigoterapie word aangedui. Die huidige studie bied 'n beskrywing van die unieke betekenisse en oplossings wat gesinne genereer tydens die veranderings wat CMS vergesel. / The present study is a qualitative ecosystemic exploration of the phenomenon known as chronic fatigue syndrome (CFS). The paradigm shift from the Newtonian epistemology to the epistemology of cybernetics, has important implication for research and the conceptualisation of CFS, as indicated in the study. The traditional, reductionist conceptualisation of CFS in research and treatment methods, is discussed. The suppositions of second order cybernetics and social constructionism, are discussed and applied in the description of two systems where CFS occurs. The research methodology of the present study is generated from the theoretical suppositions. Die implications of the use of the ecosystemic epistemology for the conceptualisation of CFS are indicated. The re-conceptualisation of CFS as a transition process is discussed and guidelines are given for future research and psychotherapy. The present study is a description of the unique meanings and solutions that the families generated during the changes that accompany CFS. / Psychology / M.A. (Kliniese Sielkunde)

Hierdie studie is 'n kwalitatiewe ekosistemiese ondersoek van die fenomeen Chroniese Moegheidsindroom (CMS) . Die paradigmaverskuiwing vanaf die Cartesiaans-Newtoniaanse epistemologie na die kubernetiese epistemologie, het 'n aantal belangrike implikasies vir die bestudering en konseptualisering van CMS, soos uiteengesit in hierdie studie. 'n Bespreking van die konseptualisering en behandeling van CMS vanuit die tradisionele, reduksionistiese navorsing word verskaf. Die aannames van twee-orde kubernetika en sosiale konstruksionisme, is bespreek en toegepas op die beskrywing van twee sisteme waarin CMS voorkom. Die navorsingsmetodologie van die studie is gegenereer op grand van die genoemde teoretiese aannames. Die implikasies van die toepassing van die ekosistemiese epistemologie vir die konseptualisering van CMS word uitgewys. Die herkonseptualisering van CMS as 'n transisieproses word bespreek en riglyne vir verdere navorsing en psigoterapie word aangedui. Die huidige studie bied 'n beskrywing van die unieke betekenisse en oplossings wat gesinne genereer tydens die veranderings wat CMS vergesel. / The present study is a qualitative ecosystemic exploration of the phenomenon known as chronic fatigue syndrome (CFS). The paradigm shift from the Newtonian epistemology to the epistemology of cybernetics, has important implication for research and the conceptualisation of CFS, as indicated in the study. The traditional, reductionist conceptualisation of CFS in research and treatment methods, is discussed. The suppositions of second order cybernetics and social constructionism, are discussed and applied in the description of two systems where CFS occurs. The research methodology of the present study is generated from the theoretical suppositions. Die implications of the use of the ecosystemic epistemology for the conceptualisation of CFS are indicated. The re-conceptualisation of CFS as a transition process is discussed and guidelines are given for future research and psychotherapy. The present study is a description of the unique meanings and solutions that the families generated during the changes that accompany CFS. / Psychology / M.A. (Kliniese Sielkunde)