Research has consistently shown schizophrenics to perform significantly poorer than normal controls on commonly used measures of neuropsychological functioning. Research on the neuropsychological functioning of first-degree relatives of schizophrenics who do not themselves have schizophrenia is comparatively sparse but suggests the likelihood of deficits in this group as well. A battery of standard neuropsychological tests was administered to three groups: first-degree relatives of schizophrenics who do not themselves have schizophrenia (FDR-SCZ), first-degree relatives of persons with major depression and bipolar disorder (FDR-MOOD), and normal controls (NC). The FDRSCZ group was not found to demonstrate significantly impaired performance relative to the other two groups on any of the hypothesized or exploratory analyses. These implications of these findings are discussed with reference to previous studies and future research.