Thesis (Ph. D.)--University of Wisconsin--Madison, 1981. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 81-91).

Thesis ()--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [89]-99).

Thesis (Ph. D.)--Lehigh University, 1997. / Includes vita. Bibliography: leaves 179-195.

Evaluation of the tableting mixtures containing the paracetamolum by the parameters of the equation of compression The diploma thesis deals with effect of paracetamol on the parameters of compression equation. These parameters characterize compression process in the individual phases of compression: precompression phase, phase of elastic deformation and phase of plastic deformation. Paracetamolum was studied in the five mixtures, where it occurred in different ratio with microcrystalline cellulose. Looseness, Carr's index and Hausner ratio were evaluated for each mixture. The sizes of reductions ai, sizes of energies Ei and Ri, "half-pressures" pHi and the velocity constants 1/ti were calculated using three-exponential equation of compression for the individual phases of pressing. The results showed poor flow properties of tableting mixtures and thus its unsuitability for direct compression. The results of the study have revealed that increasing amounts of paracetamolum in the mixture increase reduction of volume a1 and velocity of volume change 1/t1 in dependence on the amount of the extruded air and decrease the required energy due to the smooth surface and less friction during the precompression phase. Reduction of volume a2 decrease with the increase of content of paracetamol due to...

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Natália Pribylincová Consultant: Doc. RNDr. Milan Řehula, CSc. Effect of ascorbic acid on the parameters of compression equation Many mathematical models describing the compressing process are widely used in the development of new medicinal products in form of tablets. This process can be evaluated by means of compaction equations or throughout the viscoelastic properties. Compaction equation expresses dependency on height, volume or density of the used material which is being compressed by the applied compacting pressure. Based on the gained parameters, it is possible to describe specifically various stages of the compaction process, to determine characteristic properties of the studied material and accordingly to examine its mechanism. This thesis deals with the impact of the ascorbic acid on the parameters of compaction equation. The paperwork evaluates a mixture consisting of ascorbic acid (AA) and microcrystalline cellulose (MCC) in the ratio of MCC : AA 100:0, 75:25, 50:50, 25:75, 0:100. . The mostly used compression equations are described in the theoretic part. The three - exponential equation by Řehula created at the Department of Pharmaceutical Technology at Charles...

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Tisoňová Zuzana Consultant: Doc. RNDr. Milan Řehula, CSc. Compacting process is mathematically expressed by compression equations. It is characterized by various parameters of equations. The equation expresses the dependence of the volume, density and height on compacting pressure. In this paperwork, the parameters of compacting equation are evaluated and the pre-loading phase, the phase of elastic deformation and the phase of plastic deformation are studied. This thesis deals with impact of ibuprofen on the parameters of compaction equation. Five mixtures which included microcrystalline celulose and ibuprofen in different ratio 100:0, 75:25, 50:50, 25:75 and 0:100 were studied. Results were based on the three-exponential equation. They were evaluated thanks to box plots. From the results obtained, it is obvious that with decreasing amount of microcrystalline cellulose, the parameter a1 has increased and the parameter E1 also slightly has increased. The composition of the used material didn't have any huge influence on parameters 1/t1 and pH1. During the phase of elastic deformation, the parameters a2 and E2 with decreasing amount of ibuprofen have decreased. On the other hand, the...

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Jakub Šmíd Consultant: Doc. RNDr. Milan Řehula, CSc. Effect of acetylsalicylic acid on the parameters of compression equation Compacting process can be expressed mathematically by compression equations. It is characterized by various parameters. The compression equation expresses the dependence of the volume, density and height on compacting pressure. This paper evaluates the parameters of the compaction equation and study pre-loading phase, the phase of elastic deformation and the phase of plastic deformation. This thesis examines effect of acetylsalicylic acid on the parameters of compaction equation. Tablets were compressed from five mixtures. Mixtures contained acetylsalicylic acid and microcrystalline cellulose in different ratios 0:100, 25:75, 50:50, 75:25 and 0:100. The results were obtained using the three-exponential equation. Evaluation was carried out by using box plots.

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Supervisor: Doc. RNDr. Milan Řehula, CSc. Title of Dissertation: Validation of a new method for the evaluation of stress relaxation of tablets Keywords: tablets, stress relaxation test, elastic and plastic deformation The theoretical part of this thesis deals with the elastic relaxation of tablets. It describes various methods used in the evaluation of elastic recovery of tablets. The present work explores the factors affecting the elastic relaxation of tablets. The experimental part is focused on the stress relaxation test. Until present only one delay was studied. This work studies the stress relaxation after relieving tablet. The parameters A2, T2 and P2 were reviewed. The relationship between the parameters P2 and compression force relief were studied. For experiments microcrystalline cellulose Avicel PH 102 (MCC) was used. Tablets were compressed in a device used for testing the strength of the material in pressure and tension T1-FRO 50. For the determination of the stress relaxation test, the tablets were compressed with 180 sec first delay. The second delay was always 60 sec but it was measured from certain decrease of pressure (7 kN, 6 kN, 5 kN, 4 kN, 3 kN, 2 kN, 1 kN and 0.1 kN). To...

In this thesis a previously unknown mechanism of failure in multilayered slope profiles is identified. In some conditions this mechanism does not confirm to the known failure models (relating to circular failure) used in slope stability analysis. For this reason, major failures have occurred in the artificial cuts despite the fact that the limit equilibrium methods suggest that these cuts would be stable. The limit equilibrium methods were originally created to apply to earth dam walls. In the open pit mining environment, where we face inhomogeneous and inclined multilayered structures, the assumptions of these limit equilibrium methods appear to be inapplicable (e.g. assumption for the equal shear strength along the failure surface). Analysis starts with a general picture of the stress state in the highwall slope, given extant geological conditions and rock properties. The study then focuses on a comparison of the crack-tip stress changes in the rockmass with and without inclusions at the microscopic level. Basing some assumptions on binocular microscope observations of grain structures, it is possible to measure the size of the different inclusions and show that the microscopic carbon flakes present in the rock fabric make a major contribution to the failure process in a mudstone layer in the slope. The approach adopts the fracture-process zone ahead of a crack tip as the controlling parameter of flaw propagation in rock. Flaw coalescence, which is poorly accounted for in current fracture models, is attributable to two phenomena: the flaw propagation due to high level of applied stress; and the linking of fracture-process zones due to the small distance between neighbouring flaws. A condition of flaw coalescence is given based on these two mechanisms. This development allows defining of two zones along the failure surface (frictional and cohesive). In the slope-stability field the shear strength of the rock along the failure plane is a composite function of cohesive and frictional strength. For instance, the relaxation stress normal to bedding, induced by overburden removal, provides an investigation method for the determination of the weakest minerals, which may act as flaws for fracture propagation in low-porosity rock. A method has been developed to determine the critical stress for tensile fracture propagation due to the rock structure and the stress reduction normal to bedding. A proposed failure mechanism is based on the polygonal failure surfaces theory developed by Kovari and Fritz (1978), Boyd’s field observations (1983), Stead and Scoble’s (1983) analyses, Riedel (1929) Shear Fracture Model, Tchalenko and Ambraseys (1970), Gammond’s (1983) and Ortlepp (1997) observations for natural shear failures, computer modelling by McKinnon and de la Barra (1998), the results of many laboratory experiments reported by Bartlett et al. (1981) and the author’s experience. The proposed failure mechanism evaluates stability of the artificial slope profile due to the embedded weak layer structure, layer thickness, layer inclination and depth of the cut. On the basis of the observations and the above-mentioned modified fracture model, the slope profile is divided into two blocks; passive and active blocks. With this new model, it is possible to calculate slope safety factors for the slope failure cases studied in the industry. It has been found that, whereas the conventional slope stability models predict stable conditions, the new model suggests that the slope is only marginally stable (i.e. that failure can be expected). / Thesis (PhD(Mining Engineering))--University of Pretoria, 2007. / Mining Engineering / unrestricted