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Characterisation and evolution of homoimmune Streptomyces bacteriophagesGregory, Matthew Alan January 2000 (has links)
No description available.
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The interaction of the adenovirus E1B-55K protein with a histone deacetylase complex : its importance in regulation of P53 protein functions /Punga, Tanel, January 2003 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2004. / Härtill 3 uppsatser.
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Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1 /Ruas, Jorge, January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 5 uppsatser.
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Structural basis for transcription regulations in Mycobacterium tuberculosis by iron-dependent regulator and dormancy survival regulator /Wisedchaisri, Goragot. January 2005 (has links)
Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (leaves 232-250).
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Interaction of RGG and HTH motifs with nucleic acids : a study with rationally designed synthetic and recombinant polypeptidesGuarnaccia, Corrado January 2001 (has links)
No description available.
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Mechanisms of Hairy-mediated transcriptional repression during Drosophila development /Phippen, Taryn Marie. January 2001 (has links)
Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 91-109).
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The role of regulatory proteins at the FEPDGC-ENTS promoter region in escherichia coli : a new model for the fur-DNA interaction /Lavrrar, Jennifer L. January 2002 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2002. / "December 2002." Typescript. Vita. Includes bibliographical references (leaves 179-198). Also issued on the Internet.
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Molecular and genetic characterization of the function of tramtrack in dorsal appendage morphogenesis in Drosophila melanogaster /French, Rachael Louise. January 2003 (has links)
Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 133-141).
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The neural progenitor to neuron transition : role and regulation of GrouchoTLE proteinsBuscarlet, Manuel. January 2008 (has links)
Groucho/transducin-like Enhancer of split (Gro/TLE) family proteins are corepressors found as part of multiple transcriptional complexes that play significant roles during many developmental processes, including neurogenesis. This thesis sought to characterize the molecular mechanisms underlying the biological activity of Gro/TLE1. More specifically, the aim was to clarify the contribution of different transcriptional cofactors, as well as phosphorylation events induced by cofactor binding, to Gro/TLE1 ability to inhibit neuronal differentiation from proliferating neural progenitor cells. / By characterizing specific point mutations within the C-terminal domain of Gro/TLE1, we were able to selectively impair binding of Gro/TLE1 to different classes of DNA-binding proteins and then assess the effect of those mutations on Gro/TLE1 anti-neurogenic function. These studies showed that the inhibition of cerebral cortex (cortical) neuron differentiation by Gro/TLE1 requires interaction with transcription factors that use short tetrapeptide sequences, WRP(W/Y), to recruit Gro/TLE1. In contrast, interactions with proteins that either interact with the C-terminal domain of Gro/TLE1 using a different type of binding sequence, termed engrailed homology 1 (Eh1) motif, or bind to the N-terminal part of the protein, are not required for Gro/TLE1 anti-neurogenic function. / Using a similar strategy based on mutation analysis, we characterized point mutations that block the hyperphosphorylation of Gro/TLE1 induced by transcription cofactor binding ("cofactor-activated phosphorylation") without impairing cofactor binding and transcriptional corepression ability. These mutations map at phosphorylatable serine residues, Ser-286, Ser-289, and Ser298. Mutation of those residues to alanine blocks/reduces both cofactor-activated phosphorylation and anti-neurogenic activity of Gro/TLE1, demonstrating that cofactor-activated phosphorylation is required for that function. Tandem mass spectroscopy analysis showed further that Ser-286 is phosphorylated. Taken together, these findings characterize the role of cofactor-activated phosphorylation and identify residues important for this mechanism. / Our studies also showed that homeodomain-interacting protein kinase 2 (HIPK2) mediates phosphorylation of Gro/TLE1 when the latter is complexed with transcriptional partners of the WRP(W/Y) motif family. However, HIPK2 is not involved in Gro/TLE1 cofactor-activated phosphorylation. Rather, HIPK2--mediated phosphorylation is antagonistic to the latter and decreases the ability of Gro/TLE1 to interact and repress transcription with WRP(W/Y) motif proteins. / Taken together, these results improve significantly our understanding of the mechanisms underlying the anti-neurogenic function of Gro/TLE1. This information provides new insight into the regulation of mammalian neuronal development and, possibly, other developmental processes controlled by Gro/TLE proteins.
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Molecular Studies of Three Coliphage Repressor Proteins P2 C, P2 Hy dis C and Wphi C : Kinetics, Oligomeric States and Structural Studies /Henriksson Peltola, Petri, January 2007 (has links)
Diss. (sammanfattning) Stockholm : Stockholms universitet, 2007. / Härtill 3 uppsatser.
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