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Cell therapy limits loss of vision in an animal model of retinal degenerative diseaseMcGill, Trevor, University of Lethbridge. Faculty of Arts and Science January 2004 (has links)
The Royal College of Surgeons (RCS) rat was used as a model of human retinal degenerative disease, and for studying the efficacy of cell transplanation treatments. In order to characterize the spatial vision of the RCS strain, the visual acutiy and contrast sensitivity of adult non-dystrophic RCS rats was measured. The acuity and contrast sensitivity of these rats was normal. The acuity of dystrophic RCS rats was alos characterized to determine how photoreceptor degeneration affects vision. These rats progressively lost visual acuity from one month of age until elevn months of age when they were judged to be blind. The degeneration of vision in these animals was more protacted than would be predicted from previous anatomical and electrophysiological measures. Subretinal transplantation of human-derived Retinal Pigment Epithelial (RPE) cells and human Schwann cells into the dystrophic RCS rat significantly delayed the loss of visual acuity. These studies show that cell transplantation may be a viable method of limiting loss of vision in humans with retinal degenerative blinding diseases. / vii, 77 leaves ; 29 cm.
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Functionally non-adaptive retinal plasticity in rat models of human retinal degenerative diseaseMcGill, Trevor, University of Lethbridge. Faculty of Arts and Science January 2008 (has links)
The established model used for evaluating potential therapies for retinal disease
has significant limitations. A new model is proposed to account for these limitations: the
visual adaptation model. The visual adaptation model was developed to provide a novel
approach for testing potential treatments for retinal disease, and the work in this thesis
provides empirical support for this model. Specifically, we evaluated two potential
therapies for retinal degenerative disease and examined their effects on vision and retinal
anatomy. In addition, the profile of retinal reorganization and its functional correlates
were examined in RCS rats and transgenic rats which express a rhodopsin mutation;
however, immunohistological work targeted one specific line (S334ter-4). Collectively,
these studies provide evidence that supports the retinal adaptation model. These studies
also provide a novel view of retinal and visual function in retinal disease which should be
considered when evaluating treatments involving retinal degeneration. / xvii, 205 leaves : ill. ; 29 cm. --
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