Global ETD Search

1	The role of opsin expression in the development of photoreceptor topography and synapses in the fetal primate retina / Bumsted, Keely Maureen, January 1996 (has links) Thesis (Ph. D.)--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [145]-174).
2	Turning off the light response in rod and cone photoreceptors / Kennedy, Matthew James, January 2003 (has links) Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 80-91).
3	Gain control of rod and cone vision in the mammalian retina / Dunn, Felice Audris. January 2007 (has links) Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 126-138).
4	Comparisons between behavioral and electrophysiological measures of visual function in rodent models of retinal degeneration Rubin, Glen R. January 2009 (has links) (PDF) Thesis (Ph.D.)--University of Alabama at Birmingham, 2009. / Title from first page of PDF file (viewed on June 10, 2009). Includes bibliographical references.
5	Molecular determinants of cGMP-binding to chicken cone photoreceptor phosphodiesterase / Huang, Daming, January 2004 (has links) Thesis (Ph. D.)--University of Washington, 2004. / Vita. Includes bibliographical references (leaves 95-101).
6	Genetic and biochemical analysis of zebrafish with visual function defects / Taylor, Michael Robert. January 2002 (has links) Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 74-81).
7	The role of melanopsin containing retinal ganglion cells in the pupillary responses of human and non-human primates McDougal, David H. January 2008 (has links) (PDF) Thesis (Ph. D.)--University of Alabama at Birmingham, 2008. / Title from first page of PDF file (viewed Feb. 12, 2009). Includes bibliographical references (p. 136-146).
8	Activation of mTORC1 Improves Cone Cell Metabolism and Extends Vision in Retinitis Pigmentosa Mice: A Dissertation Venkatesh, Aditya 12 April 2016 (has links) Retinitis Pigmentosa (RP) is an inherited photoreceptor degenerative disease that leads to blindness and affects about 1 in 4000 people worldwide. The disease is predominantly caused by mutations in genes expressed exclusively in the night active rod photoreceptors; however, blindness results from the secondary loss of the day active cone photoreceptors, the mechanism of which remains elusive. Here, we show that the mammalian target of rapamycin complex 1 (mTORC1) is required to delay the progression of cone death during disease and that constitutive activation of mTORC1 is sufficient to maintain cone function and promote cone survival in RP. Activation of mTORC1 increased expression of genes that promote glucose uptake, retention and utilization, leading to increased NADPH levels; a key metabolite for cones. This protective effect was conserved in two mouse models of RP, indicating that the secondary loss of cones can be delayed by an approach that is independent of the primary mutation in rods. However, since mTORC1 is a negative regulator of autophagy, its constitutive activation led to an unwarranted secondary effect of shortage of amino acids due to incomplete digestion of autophagic cargo, which reduces the efficiency of cone survival over time. Moderate activation of mTORC1, which promotes expression of glycolytic genes, as well as maintains autophagy, provided more sustained cone survival. Together, our work addresses a long-standing question of non-autonomous cone death in RP and presents a novel, mutation-independent approach to extend vision in a disease that remains incurable. Autophagy Retinal Cone Photoreceptor Cells Retinal Rod Photoreceptor Cells Retinitis Pigmentosa TOR Serine-Threonine Kinases Dissertations, UMMS Cellular and Molecular Physiology Eye Diseases Ophthalmology

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