Universiẗat, Diss., 2005 u.d.T.: Stöcker, Ute: Strategien zur Revitalisierung von Hafenarealen im Binnenland--Karlsruhe.

Universiẗat, Diss., 2005--Frankfurt (Main).

Zugl.: Düsseldorf, Univ., Strassburg, Univ., Diss., 2006 u.d.T.: Denni, Karen: Die Grenze zwischen Frankreich und Deutschland (1861 - 2006): von einer Linie, die trennt, zu einer Brücke, die vereint?

Texte remanié de: Diss.--Philosophische Fakultät--Freiburg i. Br.--Albert-Ludwigs-Universität, 1988. Titre de soutenance : Zwischen Landwirtschaft und Regionalhandel : Kleinstadt und Kirche im mittelalterlichen Breisgau. / Bibliogr. p. 352-375. Index.

Zugl.: Oestrich-Winkel, Europ. Business School, Diss., 2008

Zugl.: Oestrich-Winkel/Wiesbaden, European Business School, Diss., 2008.

In the context of globalization, regions see themselves more and more exposed to a competition about qualified work force, company settlements, employment and European funds. In parallel, global challenges like an aging population or climate change ask for regional solutions and collaborations have become vital. Cross-border regions across Europe have developed to reduce barrier effects and foster new development potentials. The aim of the following study is to analyse the effects of the implementation of cross-border regions on the competitiveness of local companies and institutions. Therefore, a comparative case study of the European Region Donau-Moldau and the Euregio Meuse-Rhine has been designed. The analysis shows that the potential of CBRs relies in the fact to join forces and competencies and that these collaborations address relevant topics to foster the competitiveness.

Diss. Univ. Marc Bloch, Strasbourg / Heinrich-Heine-Univ. Düsseldorf, 2006. / Originaltitel: Die Grenze zwischen Frankreich und Deutschland (1861-2006): von einer Linie, die trennt, zu einer Brücke, die vereint? Originaltitel: Die Grenze zwischen Frankreich und Deutschland (1861 - 2006), Titel der Orginaldiss.

In the everlasting battle against cancer the development of drugs targeting new therapeutic pathways is of crucial importance. In the attempt to develop new anticancer agents we have synthesized a library of anthraquinone compounds that show selectivity against leukemia. Mechanistic evaluation of the lead compound reveal that this class of compounds achieve their effects through inhibition of MDM2-MDM4 heterodimer and upregulation of the tumor suppressor p53. Computer aided rational design resulted in the development of a number of compounds with activities in the nanomolar range against various cancer cells. Analysis of the physicochemical properties of selected compounds allowed for their evaluation as potential drug candidates. The successful development of non-toxic formulations permits for the further in vivo investigation of the compounds. Click reactions have found wide spread applications in sensing, materials chemistry, bioconjugation, and biolabeling. A number of very useful click reactions have been discovered, which allow for various applications. In bioconjugation applications, the ability to conduct a secondary conjugation will be very useful in, e.g., protein pull down and binding site identification. Along this line, we describe a neighboring group-assisted facile condensation between an aldehyde and a vicinal aminothiol moiety, leading to the formation of benzothiazoles. The conversion is completed within 5 minutes at low micromolar concentrations at ambient temperature. The facile reaction was attributed to the presence of a neighboring boronic acid, which functions as an intramolecular Lewis Acid in catalyzing the reaction. The boronic acid group is compatible with most functional groups in biomolecules and yet can also be used for further functionalization via a large number of well-known coupling reactions.

Thesis (Ph. D.)--Utrecht University, 2002. / Includes bibliographical references (p. 163-171).