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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Genetic associations of rheumatoid arthritis in Chinese. / CUHK electronic theses & dissertations collection

January 2011 (has links)
Li, Martin. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 187-208). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.
2

Genetic markers of rheumatoid arthritis in a Western Cape black and coloured population

Pokorny, Ljubica January 1996 (has links)
Thesis (MTech (Medical Technology))--Cape Technikon, 1996. / Intensive investigations in many different populations over the last decade, have indicated a failure to understand the inheritance of rheumatoid arthritis (RA). It was hoped that genes within the class II region of the major histocompatibility complex (MHC) could shed some light on the inheritance of this autoimmune disease and which are now known without doubt, to confer susceptibility to the disease. Genetic studies of RA have concentrated primarily on its autoimmune nature and several investigations of MHC class II molecules, have demonstrated an association between specific HLA alleles and susceptibility to RA, in particular the DRB1 *04 and DRB1 *01 alleles. The HLA system is known to be associated with many diseases involving an immune aetiology. The structural features of specific DR and DQ genes give clues to the molecular mechanisms by which these alleles are associated with RA. It has been found by many investigators that there is more than one susceptibility allele for RA at the DRB1 locus. Questions arise whether the DRB1 molecule itself directly contributes to the pathogenesis of RA and why some DRB1 genes carrying DRBI *04 alleles, are not associated with RA.

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