abstract: Optimization of on-demand transportation systems and ride-sharing services involves solving a class of complex vehicle routing problems with pickup and delivery with time windows (VRPPDTW). Previous research has made a number of important contributions to the challenging pickup and delivery problem along different formulation or solution approaches. However, there are a number of modeling and algorithmic challenges for a large-scale deployment of a vehicle routing and scheduling algorithm, especially for regional networks with various road capacity and traffic delay constraints on freeway bottlenecks and signal timing on urban streets. The main thrust of this research is constructing hyper-networks to implicitly impose complicated constraints of a vehicle routing problem (VRP) into the model within the network construction. This research introduces a new methodology based on hyper-networks to solve the very important vehicle routing problem for the case of generic ride-sharing problem. Then, the idea of hyper-networks is applied for (1) solving the pickup and delivery problem with synchronized transfers, (2) computing resource hyper-prisms for sustainable transportation planning in the field of time-geography, and (3) providing an integrated framework that fully captures the interactions between supply and demand dimensions of travel to model the implications of advanced technologies and mobility services on traveler behavior. / Dissertation/Thesis / Doctoral Dissertation Civil, Environmental and Sustainable Engineering 2018