No description available.

Reducers are commonly used in many types of machines to reduce the speed and increase the torque of motors. For general industrial applications, the reduction ratio of a reducer is usually limited in consideration to its size. To provide high reduction ratios, harmonic drives (speed reducers) can be made very compact and lightweight and thus have been popular with robot manufactures and in other applications where weight is critical. In this study, an innovative design for reducers composed of planar cams and roller followers with high reduction ratios is proposed. It uses the relative motion between rollers and their cams to generate a high reduction ratio. In this thesis, the synthesis procedure of the reducer and the analysis results of the kinematic and dynamic characteristics based on the design parameters are also described. Furthermore, the experiments for testing and verifying the characteristics of the reducer are presented. Finally, a set of design parameters which meets the demand of an application is found by optimization methods.

No description available.

In this thesis we study the possibilities of designing an application to design a production line for bending of profile sheet. We discuss step by step the process of profile design, flower pattern, production line benches and the rollers, that will shape the metal sheet into the final form. We discuss the algorithms used to create different types of points placed in the contour of roller to improve the production of metal profile. As result of our work software was developed, which is able to fully support the whole process of production and it is used in practice.

Orthodontic brackets undergo resistance during sliding that includes classical friction, binding, and notching. Current bracket systems are hampered by these challenging forces. As a result, the clinician usually needs to apply additional forces to overcome the resistance which increases the risk of root resorption and discomfort for the patient. This study evaluated frictional properties of a novel bracket that had polytetrafluoroethylene (Teflon™) coated rollers in its design. Five types of brackets (n = 10, each), including a passive self-ligating bracket, a traditional ligated bracket, a three-dimensionally printed direct metal laser sintering (DMLS) bracket with and without Teflon™ rollers, and computer numeric controlled (CNC) machine milled bracket with Teflon™ rollers were tested. The peak resistance values were assessed at 0°, 4°, and 8° of tip on a 0.019 x 0.025” arch wire. At 8° of tip, the DMLS and the CNC milled bracket systems, both with Teflon™ rollers, exhibited less friction as compared to the other brackets tested (p

The work is a project of a component that allows lift transform rollers skewing. Three possible ways of construction are introduced. Their advantages and disadvanatages are mentioned. The best option was selected and checked by FEM. Prestressed bolted connection was also worked out. In the conclusion of the paper there is a source code of the computer programme for maximum rollers skew calculation.

A terapia fotodinâmica (TFD) é uma técnica não invasiva usada no tratamento de lesões de pele, como câncer basocelular, queratose actínica, e doença de Bowen, dentre outros. Basicamente, a combinação da administração de um fotossensibilizador (FS), com a irradiação de luz adequada e o oxigênio celular, gera uma série de reações oxidativas que provocam a morte do tecido. Contudo, o principal efeito colateral desta terapia é a fotossensibilidade prolongada ocasionada pela administração de fotossensibilizadores sistêmicos. Por outro lado, a via tópica não apresenta esta limitação, pois o tratamento é realizado no local da lesão através de pró-drogas. O ácido aminolevulínico, ALA, está entre as pró-drogas mais utilizadas para indução do acúmulo do agente fotossensível na pele, a protoporfirina IX, ou PpIX. Contudo, a via tópica não permite penetração suficiente e homogênea do creme para o tratamento de lesões espessas. Visando a melhoria da TFD, foram realizados estudos in vivo e in vitro. Nos estudos in vivo, técnicas mecânicas - rolos de microagulhas, tape stripping e injeção livre de agulhas foram estudadas buscando encontrar a mais eficiente nos quesitos de: promoção da penetração da pró-droga no tecido, distribuição homogênea e de indução do acúmulo de PpIX. Para isto, foi o utilizado o modelo porcino, in vivo, conhecido como o modelo que possui a pele mais similar à pele humana. Os resultados in vivo mostram que as técnicas têm resultados similares na produção de PpIX e na distribuição de porfirina mais homogênea na superfície. Além disso, todas as técnicas estudadas in vivo têm se destacado em promover uma entrega mais homogênea de ALA também na profundidade da pele quando comparadas ao grupo controle. Nos estudos in vitro, foram examinadas possíveis diferenças na capacidade de formação da PpIX e/ou de resistência de células ao tratamento por TFD entre células expressando diferentes características de transição epitélio-mesenquimal. Os resultados in vitro indicam que as células com características epitélio-mesenquimal mais acentuadas produzem mais PpIX e são mais responsivas à TFD. Estes resultados indicam que a TFD tem maior efetividade no tratamento de células mesenquimais, e os estudos in vivo mostram que no tecido normal há maior seletividade de produção na camada da epiderme e apêndices da pele sugerindo que a terapia pode ser utilizada com maior eficiência em lesões superficiais e, até mesmo diminuir as taxas de recorrência devido a heterogeneidade de distribuição do creme na pele quando umas das técnicas mecânicas são utilizadas. / Photodynamic therapy (PDT) is a noninvasive technique used to treat skin lesions, such as basal cell cancer, actinic keratosis and Bowen\'s disease. Basically, the administration of a photosensitizer (PS), combined with the illumination of adequate light and the cellular oxygen, generate a series of oxidative reactions that cause tissue death. However, the major side effect of the treatment is prolonged photosensitivity caused by the systemic administration of photosensitizers. On the other hand, the topical therapy does not show this limitation, and it is performed at the lesion site via prodrugs. The aminolevulinic acid, ALA, is the most popular pro-drug in topical PDT. This prodrug induces PpIX production that is a photosensitive porphyrin. However, when ALA is used topically, the cream does not provide enough or homogeneous penetration for the treatment of deep lesions. Therefore, with the aim of improving PDT therapy, studies in vivo and in vitro were performed. In the in vivo analysis, mechanical techniques - microneedle roller, tape stripping, and needle-free injection- were studied looking for the most effective regarding to improve the following purposes: promoting penetration of the prodrug into the tissue, homogeneous distribution, and at inducing PpIX accumulation. The evaluations were made by fluorescence spectroscopy, biopsy of skin, and fluorescence images, using the porcine model, in vivo, known as the most similar of human skin tissue. The in vivo results showed that all techniques have similar results in the production of PpIX, and perform a more homogeneous porphyrin distribution in the skin surface. Moreover, all the techniques have excelled in promoting a homogeneous distribution of PpIX in the deep of the skin when compared to the control group. In addition to the skin penetration, studies of PpIX production were performed in vitro in cells expressing different levels of epithelial-mesenchymal transition characteristics. The studies were made in regard to a possible difference in PpIX formation capacity and / or a resistance to the PDT treatment. The in vitro results showed that cells with more epithelial-mesenchymal characteristics produce more PpIX and are more responsive to the PDT therapy. These results indicate that PDT therapy may have a better effectiveness in the treatment of mesenchymal cells and also the results in vivo showed that the ALA-induced PpIX in normal tissue seems to be selective to epidermal and skin appendages, indicating that the topical therapy may be used with a higher efficiency in superficial injuries providing lower recurrence rates when they combine with one of the techniques studied.

Detta examensarbete har gjorts på uppdrag av Rottne Industri AB och berör matarhjulens dubbinträngning i virket. Matarhjulen sitter monterade i skördaraggregatet i skördaren, en skogsmaskin som används vid skogsavverkning. Då inträngningen, som uppstår av dubbarna på matarhjulen, är för stor (>5mm) bildas skador på virket vilket är ett utbrett problem inom skogsmaskinindustrin. Studien kartlägger de vanligaste dubbmönstrens skadeåverkan under kontrollerade och vetenskapliga förhållanden där testerna är designade för att efterlikna verklig skogsavverkning. I studien utförs två tester. Det första visar sambandet mellan presskraft och inskjutningsmått för respektive dubbmönster. Det andra är utformat för att se förmågan att överföra kraft mellan dubbmönstret och virket, så kallad skjuvdragning. Sju dubbmönster kommer att undersökas i studien. Om man ser till den tekniska information utvunnen ur testerna så har finnskogsvalsen med dubbla ribbor ett klart övertag speciellt i skjuvningssituationer. Däremot måste fler aspekter tas med i beräkningarna vid valet av dubbmönster. En av dem är tendenser för barkpackning i mönstrets håligheter. Då finnskogsvalsen med dubbla ribbor är ett förhållandevis tätt mönster måste omfattande undersökningar göras angående den aspekten innan det kan tas i fullt bruk. / This diploma work has been done on commission by Rottne Industri AB and affects the feed rollers and their stud’s penetration in timber. The feed rollers are mounted in the harvester head which sits on a timber cutting machine used for harvesting wood (harvester). When the damage caused by the studs is too deep the timber is permanently damaged which is a big problem for the industry. Two tests is carried out in the study. The first shows the connection between the pressing force and the damage depth made by the studs. The second test is designed to show the stud patterns ability of transferring power from the feed rollers to the timber. Seven stud patterns are examined in this study. According to the technical information retrieved by the tests finnskogsvalsen with double ribs has the best characteristic abilities, especially in the pull test. But more aspects has to be dealt with before this pattern can be used in the reality. One obvious problem this stud pattern could have is a tendency to store bark during operation, this is a major problem in the woods.

<p>Detta examensarbete har gjorts på uppdrag av Rottne Industri AB och berör matarhjulens dubbinträngning i virket. Matarhjulen sitter monterade i skördaraggregatet i skördaren, en skogsmaskin som används vid skogsavverkning. Då inträngningen, som uppstår av dubbarna på matarhjulen, är för stor (>5mm) bildas skador på virket vilket är ett utbrett problem inom skogsmaskinindustrin. Studien kartlägger de vanligaste dubbmönstrens skadeåverkan under kontrollerade och vetenskapliga förhållanden där testerna är designade för att efterlikna verklig skogsavverkning.</p><p>I studien utförs två tester. Det första visar sambandet mellan presskraft och inskjutningsmått för respektive dubbmönster. Det andra är utformat för att se förmågan att överföra kraft mellan dubbmönstret och virket, så kallad skjuvdragning. Sju dubbmönster kommer att undersökas i studien.</p><p>Om man ser till den tekniska information utvunnen ur testerna så har finnskogsvalsen med dubbla ribbor ett klart övertag speciellt i skjuvningssituationer. Däremot måste fler aspekter tas med i beräkningarna vid valet av dubbmönster. En av dem är tendenser för barkpackning i mönstrets håligheter. Då finnskogsvalsen med dubbla ribbor är ett förhållandevis tätt mönster måste omfattande undersökningar göras angående den aspekten innan det kan tas i fullt bruk.</p> / <p>This diploma work has been done on commission by Rottne Industri AB and affects the feed rollers and their stud’s penetration in timber. The feed rollers are mounted in the harvester head which sits on a timber cutting machine used for harvesting wood (harvester). When the damage caused by the studs is too deep the timber is permanently damaged which is a big problem for the industry.</p><p>Two tests is carried out in the study. The first shows the connection between the pressing force and the damage depth made by the studs. The second test is designed to show the stud patterns ability of transferring power from the feed rollers to the timber. Seven stud patterns are examined in this study.</p><p>According to the technical information retrieved by the tests finnskogsvalsen with double ribs has the best characteristic abilities, especially in the pull test. But more aspects has to be dealt with before this pattern can be used in the reality. One obvious problem this stud pattern could have is a tendency to store bark during operation, this is a major problem in the woods.</p>

A terapia fotodinâmica (TFD) é uma técnica não invasiva usada no tratamento de lesões de pele, como câncer basocelular, queratose actínica, e doença de Bowen, dentre outros. Basicamente, a combinação da administração de um fotossensibilizador (FS), com a irradiação de luz adequada e o oxigênio celular, gera uma série de reações oxidativas que provocam a morte do tecido. Contudo, o principal efeito colateral desta terapia é a fotossensibilidade prolongada ocasionada pela administração de fotossensibilizadores sistêmicos. Por outro lado, a via tópica não apresenta esta limitação, pois o tratamento é realizado no local da lesão através de pró-drogas. O ácido aminolevulínico, ALA, está entre as pró-drogas mais utilizadas para indução do acúmulo do agente fotossensível na pele, a protoporfirina IX, ou PpIX. Contudo, a via tópica não permite penetração suficiente e homogênea do creme para o tratamento de lesões espessas. Visando a melhoria da TFD, foram realizados estudos in vivo e in vitro. Nos estudos in vivo, técnicas mecânicas - rolos de microagulhas, tape stripping e injeção livre de agulhas foram estudadas buscando encontrar a mais eficiente nos quesitos de: promoção da penetração da pró-droga no tecido, distribuição homogênea e de indução do acúmulo de PpIX. Para isto, foi o utilizado o modelo porcino, in vivo, conhecido como o modelo que possui a pele mais similar à pele humana. Os resultados in vivo mostram que as técnicas têm resultados similares na produção de PpIX e na distribuição de porfirina mais homogênea na superfície. Além disso, todas as técnicas estudadas in vivo têm se destacado em promover uma entrega mais homogênea de ALA também na profundidade da pele quando comparadas ao grupo controle. Nos estudos in vitro, foram examinadas possíveis diferenças na capacidade de formação da PpIX e/ou de resistência de células ao tratamento por TFD entre células expressando diferentes características de transição epitélio-mesenquimal. Os resultados in vitro indicam que as células com características epitélio-mesenquimal mais acentuadas produzem mais PpIX e são mais responsivas à TFD. Estes resultados indicam que a TFD tem maior efetividade no tratamento de células mesenquimais, e os estudos in vivo mostram que no tecido normal há maior seletividade de produção na camada da epiderme e apêndices da pele sugerindo que a terapia pode ser utilizada com maior eficiência em lesões superficiais e, até mesmo diminuir as taxas de recorrência devido a heterogeneidade de distribuição do creme na pele quando umas das técnicas mecânicas são utilizadas. / Photodynamic therapy (PDT) is a noninvasive technique used to treat skin lesions, such as basal cell cancer, actinic keratosis and Bowen\'s disease. Basically, the administration of a photosensitizer (PS), combined with the illumination of adequate light and the cellular oxygen, generate a series of oxidative reactions that cause tissue death. However, the major side effect of the treatment is prolonged photosensitivity caused by the systemic administration of photosensitizers. On the other hand, the topical therapy does not show this limitation, and it is performed at the lesion site via prodrugs. The aminolevulinic acid, ALA, is the most popular pro-drug in topical PDT. This prodrug induces PpIX production that is a photosensitive porphyrin. However, when ALA is used topically, the cream does not provide enough or homogeneous penetration for the treatment of deep lesions. Therefore, with the aim of improving PDT therapy, studies in vivo and in vitro were performed. In the in vivo analysis, mechanical techniques - microneedle roller, tape stripping, and needle-free injection- were studied looking for the most effective regarding to improve the following purposes: promoting penetration of the prodrug into the tissue, homogeneous distribution, and at inducing PpIX accumulation. The evaluations were made by fluorescence spectroscopy, biopsy of skin, and fluorescence images, using the porcine model, in vivo, known as the most similar of human skin tissue. The in vivo results showed that all techniques have similar results in the production of PpIX, and perform a more homogeneous porphyrin distribution in the skin surface. Moreover, all the techniques have excelled in promoting a homogeneous distribution of PpIX in the deep of the skin when compared to the control group. In addition to the skin penetration, studies of PpIX production were performed in vitro in cells expressing different levels of epithelial-mesenchymal transition characteristics. The studies were made in regard to a possible difference in PpIX formation capacity and / or a resistance to the PDT treatment. The in vitro results showed that cells with more epithelial-mesenchymal characteristics produce more PpIX and are more responsive to the PDT therapy. These results indicate that PDT therapy may have a better effectiveness in the treatment of mesenchymal cells and also the results in vivo showed that the ALA-induced PpIX in normal tissue seems to be selective to epidermal and skin appendages, indicating that the topical therapy may be used with a higher efficiency in superficial injuries providing lower recurrence rates when they combine with one of the techniques studied.