Thesis (doctoral)--Rijksuniversiteit te Utrecht, 1981. / Includes bibliographical references (p. 161-169).

Thesis (M. D. S.)--University of Hong Kong, 2009. / Includes bibliographical references (p. 111-119).

Thesis (doctoral)--University of Oslo, 1980. / Includes reprints of 7 papers by author.

Indiana University-Purdue University Indianapolis (IUPUI) / Objective: This study synthesized electrospun polymer-based scaffolds containing ciprofloxacin (CIP) and doxycycline (DOX), as a scaffold mimic of Double Antibiotic Paste (DAP) and determined, in vitro, its mechanical properties, chemical composition, and antimicrobial effectiveness against multiple endodontic bacterium. Methods: Polydioxanone sutures (PDS) were dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFP), mixed with CIP/DOX (i.e., 50%), and electrospun under optimized conditions into fibrous scaffolds. Tensile testing was used to evaluate the mechanical properties. Antimicrobial efficacy was determined over time using aliquots collected at 1, 4, 7, 14 day and agar diffusion assays. Two-Way Anova. Significance P < 0.05. Results: Tensile strength (MPa) of the CIP/DOX scaffold did not show significant difference from the control (pure PDS). Elongation at break (%) did show a significant difference between CIP/DOX scaffolds and the control group. Young’s modulus of elasticity (MPa) showed a significant difference between CIP/DOX scaffolds and the control. CIP-containing scaffolds did not inhibit Gram-negative (F. nucleatum and P. gingivalis) bacteria as effectively when compared to Gram-positive bacteria (E. faecalis and S. gordina). DOX-containing scaffolds showed less inhibition against Gram-positive (E. faecalis and S. gordina) bacteria then Gram-negative bacteria (F. nucleatum and P. gingivalis). In combination, CIP/DOX scaffolds showed significant inhibition against G(-) and G(+) bacteria. Conclusion: Electrospun double antibiotic scaffold demonstrated increased antimicrobial efficacy proving the potential for future clinical use to disinfect the RCS in permanent immature necrotic teeth to aid in regenerative treatment and or in persistent infections.

Indiana University-Purdue University Indianapolis (IUPUI) / A modified double-blind method of investigation was used in which the pulps of 52 monkey teeth were surgically exposed and left open to the oral environment for a period of 24 hours. One-half of the exposed pulps were treated with an antibiotic preparation and one-half with a pure starch control. The antibiotic compound consisted of erythromycin estolate 10 percent, streptomycin sulfate 10 percent, and starch q. s. as the vehicle. The teeth were extracted at 30 and 90 day intervals after treatment and histologically evaluated. Inflammation of a varying degree was observed in all of the teeth treated with either the antibiotic preparation or the starch control. However, those teeth treated with the antibiotic capping material exhibited much less inflammation than did the great majority of teeth treated with the starch control, in which abscess formation and necrosis were frequently observed. The pulps of those teeth treated with the antibiotic capping material demonstrated a decidedly more favorable reaction than did those pulps treated with the starch capping material. Calcific repair at the exposure site was not observed to be complete in any instance. The histologic findings for the antibiotic treated teeth were encouraging and warrant additional investigations of longer duration.

Endodontic or root canal treatment is one of the most important dental procedures employed in modern dentistry. Although there have been many results in surgical simulation in the past two decades, little work has been done on endodontics. The objective of this thesis is to explore critical issues for simulating root canal procedures effectively and efficiently, and to develop an interactive virtual environment featured with both visual and haptic feedback to facilitate endodontic training, which opens new roads to the research of root canal simulation and endodontic training. Beyond endodontics, the results of this work can be extended and applied to other kinds of medical simulation and biomechanical modeling, especially the simulations featured with interactions between soft tissue and solid tool objects. / This work covers both theories and methodologies related to the interactive endodontic simulation and validation, including dynamic modeling, visual and haptic display, model validation and statistical learning. We focus on the simulation of the most critical step in the entire endodontic procedure---shaping root canal with endodontic files. There are four major contributions of this thesis. First, we propose a dynamic model to simulate endodontic shaping operations, which is a smoothed particle based dynamic model derived for the pulpal tissue coupled with a finite element model for the endodontic files. This approach effectively characterizes the special properties and constraints associated with both the pulpal tissue and the endodontic files. Second, we implement the derived dynamic model and build up the virtual environment for endodontic simulation with both graphic and haptic interfaces. Third, we design a novel Robotic Endodontic Measurement System to acquire real haptic data of interactions between root canal and endodontic files during endodontic shaping, and propose an experimental validation method to evaluate the performance of derived dynamic model. Finally, we propose a support vector regression model to accurately characterize the input-output haptic mapping for endodontic shaping operation. The optimized parameters of this model can be learned from robotic endodontic measurements with RBF kernel. / Li Min. / "December 2005." / Adviser: Yun-Hui Liu. / Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6554. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2005. / Includes bibliographical references (p. 108-116). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts in English and Chinese. / School code: 1307.

Thesis (M.S.)--West Virginia University, 2001. / Title from document title page. Document formatted into pages; contains xi, 61 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 34-37).

Thesis (M.S.)--West Virginia University, 2002. / Title from document title page. Document formatted into pages; contains viii, 51 p. : ill. Includes abstract. Includes bibliographical references (p. 39-42).

Thesis (M.S.)--University of Michigan, 1986.

Thesis (doctoral)--Münster in Westfalen, 1934.