The studies reported in this thesis aim to provide insights on the process of navigation while driving. Driving requires processing and monitoring multiple tasks and sources of information. Navigation while driving increases the cognitive load of the driving task. Offloading the task of navigation to navigation aid systems such as GPS has potential disadvantages for our spatial memory skills. In this thesis, we introduce useful cues and skills to improve the performance of drivers in a variety of situations where they must navigate without the help of GPS. We used a motion simulator with six degrees of freedom to simulate various virtual reality driving scenarios that combine both visual and vestibular cues. In the following chapters, we report the effects of landmark cues, vestibular cues, self-reported mood disorders (e.g., depression, anxiety, and stress), individual differences at the visual spatial level (e.g., working memory span and mental rotation skills), age, and self-reported navigation skills on drivers’ route learning. We showed that successful navigation in various navigational situations depends on the type of landmarks available in the environment and the specific visual-spatial skills of drivers. We showed that vestibular self-motion cues improve egocentric route learning. Depression, anxiety, and stress affected drivers' route learning ability and dependency on GPS. We observed no deficit in age-related navigation performance when older drivers were able to use an egocentric frame of reference, however there was less optimal navigation performance of older drivers when wayfinding required an allocentric frame of reference. Overall, the application of the findings of this thesis may lead to an increase in efficacy and success in navigation performance and wayfinding while driving. / Thesis / Candidate in Philosophy / This thesis focuses on enhancing our understanding of wayfinding while driving in young and older adults. Using a driving simulator, we ran various virtual reality experiments to examine the underlying mechanisms of navigation while driving and ways to improve wayfinding of drivers. We identified useful cues for route learning in different environments where there were no navigation aid systems. We examined correlations between various spatial skills and performance that may improve drivers' wayfinding in unfamiliar environments. Furthermore, we assessed age-related effects on route learning and potential interventions to improve navigation in older drivers. The findings from the experiments reported in this thesis introduce the principle of route learning while driving in terms of how various internal and external factors can affect it. Drivers can incorporate these findings into their navigation tasks to overcome the wayfinding challenges that they encounter when driving in unfamiliar environments.