While typical telemetry processing systems are fixed, ground-based assets, certain mission profiles or telemetry acquisition models may involve telemetry processing systems which reside on other platforms, such as ships, mobile vehicles, or airplanes. The design and implementation of telemetry processing systems for these platforms poses unique challenges, which may include requirements for unusual mechanical packaging, heightened electromagnetic sensitivity, or specialized electrical interfaces. This paper presents some of the key challenges involved in the design and implementation of an airborne telemetry processing system and discusses how lessons learned from solving these challenges may be applied to future telemetry processing system designs.