La síntesis de tejidos, es la etapa final de todo acto quirúrgico teniendo como finalidad la cicatrización de los tejidos. Los adhesivos tisulares a base de cianoacrilato presentan la propiedad de polimerizar al contacto con fluidos biológico, lo cual consigue una buena fuerza de atracción entre los tejidos afrontados, además de ser biocompatible y biodegradable. El objetivo de la investigación es determinar la efectividad clínica para la cicatrización de las heridas incisionales post-exodoncia del adhesivo tisular a base de cianoacrilato en comparación a la de la sutura seda negra trenzada 3.0 El estudio se realizó en 26 pacientes entre 13 y 17 años de edad, distribuidos en dos grupos: grupo control (seda negra trenzada) y grupo experimental (adhesivo tisular a base de cianoacrilato). Las evaluaciones clínicas se efectuaran a los 30 min, 24h., 72h. y 7 días post operatorio. Las variables a evaluar fueron afrontamiento de la herida, sangrado, grado de edema, apertura bucal y dolor. El adhesivo tisular mostró ser al menos tan efectivo como la sutura convencional para el tratamiento de heridas quirúrgicas post exodoncia de terceros molares. Palabras claves (DeCS): adhesivo tisular, cianoacrilato, síntesis de tejidos. / It is the final stage of any surgery procedure having a good/well healing of tissues. Tissue adhesives based on cyanoacrylate have the property of curing upon contact with biological fluids, which get to enforce the attraction among faced tissues. In addition to being biocompatible and biodegradable. The objective was to determinate the effectiveness in the healing of surgical wounds post removal of mandibular third molar of the Tissue adhesive based on cyanoacrylate compared to conventional suture 3.0 The study was carried out on 26 teenagers’ patients who needed impacted mandibular third molar removal. They were distributed into two groups: control group (suture) and experimental group (tissues adhesive). The clinical evaluations were effected after surgery: 30 minutes, 24 hours, 72 hours, and 7 days. The variables evaluated were: inflammation, pain, hemostatic effect (bleeding), and confrontation of the wound. The tissues adhesive showed to be effective to stop bleeding and to maintain a closed wound. Finally the adhesive was the similar effectiveness as the conventional suture for the treatment of surge wounds post exodoncia. Key words: Tissue adhesive, cyanoacrylate, wound healing.