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Impact of Diabetes Mellitus and Associated Changes on Skeletal Muscle and its Stem Cell Population / Satellite Cells in Diabetes MellitusD'souza, Donna M. January 2016 (has links)
Diabetes Mellitus is chronic lifelong condition that continues to be a global health concern. Despite the development of insulin therapy in 1921, many diabetics are likely to endure a number of co-morbidities that impact their quality of life. Today, the search for additional diabetic therapies incorporates the investigation of various organ systems for their potential in attenuating disease development. Skeletal muscle is a striated tissue that is integral to metabolism, movement, and overall wellbeing, yet its significance to Diabetes Mellitus remains understudied, as compared to other metabolic tissues. Previous work has identified that diabetes promotes adverse changes to skeletal muscle physiology, function, and morphology, contributing to a complication referred to as diabetic myopathy. The capacity to adapt to changing internal and external cues, as achieved through skeletal muscle plasticity, permits the maintenance of skeletal muscle health; a term encompassing its metabolism, function, and/or structure. This malleability is primarily regulated by the function of muscle progenitor stem cells, referred to as satellite cells. While past research has shown that satellite cells are hindered in various diabetic states, the precise mechanisms through which these observations occur remain to be elucidated. The data presented herein identify impaired satellite cell activation in two sub-types of diabetes (Pre-Diabetes and Type 1 Diabetes), and shows that such results are mediated by alterations to intrinsic signalling cascades. Additional insight into a potential unifying mechanism mediating this response led to the identification of Lipocalin-2 and its influence on satellite cell function and muscle plasticity. The results uncovered in these studies have enhanced our understanding of the response of satellite cells in diabetes, and have identified a prospective therapeutic target for the attenuation of diabetic myopathy. / Dissertation / Doctor of Philosophy (PhD)
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Examination of Water Drilling Success Rate Using Satellite Imagery in the Central Plateau Region, HaitiBischoff, Kristen L. 15 July 2008 (has links)
No description available.
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COLLISON PREDICTION AND AVOIDANCE OF SATELLITES IN FORMATIONSYED, ANEES January 2004 (has links)
No description available.
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A FLEXIBLE FRAMEWORK FOR EPHEMERIDES CALCULATIONSVANDIKE, JOHN LAWRENCE January 2005 (has links)
No description available.
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USE OF NEAR-FROZEN ORBITS FOR SATELLITE FORMATION FLYINGDAVIDZ, HEIDI L. 11 October 2001 (has links)
No description available.
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Global Positioning System Interference and Satellite Anomalous Event MonitorMarti, Lukas January 2004 (has links)
No description available.
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Antenna Performance Analysis for the Nationwide Differential Global PositioningBarton, Ian M. January 2005 (has links)
No description available.
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Analyzing the performance of new TCP extensions over satellite linksHayes, Christopher January 1997 (has links)
No description available.
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Geodynamical analysis of the Iranian Plateau and surrounding regionsAsgharzadeh, Mohammad Forman 08 March 2007 (has links)
No description available.
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Computer Vision Localization Based On Pseudo-SatellitesHuggins, Kevin Robert January 2009 (has links)
No description available.
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