A self-contained self-rescue unit is a device that is used in the mining industry in case of fires or release of toxic gases that depletes or contaminates breathable oxygen in the surrounding atmosphere. These units are the first line of defense by providing oxygen in a closed breathing cycle, allowing personnel to get themselves to safety. The goal of this project was to design a unit that is more comfortable to carry during the daily operations in and outside the mines. A unit that is easier to done and less likely to damage the users and/or surrounding mining equipment. It is developed in close collaboration with Atlas Copco, as the main sponsor, as well as Dräger and personnel working at Zink Gruvan Mining.  The result is a unit with an operational time of twenty minutes and a reduced size and weight. It’s position can be adjusted to be worn around the waist or the chest, depending on the tasks the user performs, as well as simplifying the donning procedure.

Antimicrobial resistance (AMR) has been classified as one of the phenomena that belongs to the current top threats to human health. AMR is the process where bacteria become resistant to the antimicrobial drug and renders the antibiotic ineffective. This phenomenon is increasing exponentially due to misuse and overuse of antibiotics and is responsible for 700,000 annual deaths globally. If the contributing factors to AMR remain persistent, the estimated amount of annual deaths will increase to the exorbitant figure of 10 million by 2050. The inappropriate waste discharge from antibiotic manufacturing plants is the third major cause contributing to AMR. For this reason, environmental sustainability within the pharmaceutical industry is tightly linked to human health, and therefore, the importance of environmental risk management becomes crucial. Pharmaceutical supply chains are extremely complex, fragmented, and rigid due to the highly regulated environment and global distribution of the chains. Constant availability is sometimes compromised, and this leads to national shortages of antibiotics, which increase AMR. Therefore, supply chain sustainability risks (SCSRs) need to be thoroughly assessed and managed. The thesis aims to identify the sustainability risks that threaten the constant supply of antibiotics and further provide a comprehensive and sufficient framework on how to assess and manage SCSRs within the pharmaceutical industry. This research is based on the review of existing literature, followed by an empirical study that included a case study of two specific antibiotics relevant to the Swedish market. The analysis of publicly available databases, together with the qualitative interviews, revealed that the most susceptible node of the supply chain resides in the primary manufacturing stage. The most relevant SCSRs have been identified, and an adapted framework is suggested. The role of regulatory agencies has been demonstrated to be fundamental to achieve change concerning environmental progress. Further research needs to be implemented for the validation of the suggested framework within a practical context.