In this thesis, a novel pre-coded direct-sequence code division multiple access (DS-CDMA) associated with the multiple-input multiple-output (MIMO) antennas, along with Alamouti¡¦s space-time block code (ST-BC) is considered. In the transmitter, the idea of hybrid pre-coded is exploited; it can be employed to counteract the inter-symbol interference (ISI) introduced by the channel fading duo to multipath propagation, and can be used to exacting the full information of channel impulse response (CIR) in the receiver for semi-blind channel estimation. Under this transceiver framework, we develop a semi-blind adaptive MIMO-CDMA receiver, based on the linearly constrained constant modulus (LCCM) criterion, for symbol recovery. Furthermore, to reduce the complexity of receiver design, the framework of the generalized sidelobe canceller (GSC) associated with the recursive least-squares (RLS) algorithm is adopted, and the gradient approach is applied to track the desired user¡¦s amplitude, simultaneously, and is named as the GSC-CM-IQRD-RLS algorithm. Via computer simulations, the superior performance and the advantages of proposed scheme is verified; it outperforms the conventional LCMV-based algorithm, and slightly better than the convention CM-GSC-RLS receiver, with the paid of spectral efficient.