Yes / This article proposes an approach named SafeML II, which applies empirical cumulative distribution function-based statistical distance measures in a designed human-in-the loop procedure to ensure the safety of machine learning-based classifiers in autonomous vehicle software. The application of artificial intelligence (AI) and data-driven decision-making systems in autonomous vehicles is growing rapidly. As autonomous vehicles operate in dynamic environments, the risk that they can face an unknown observation is relatively high due to insufficient training data, distributional shift, or cyber-security attack. Thus, AI-based algorithms should make dependable decisions to improve their interpretation of the environment, lower the risk of autonomous driving, and avoid catastrophic accidents. This paper proposes an approach named SafeML II, which applies empirical cumulative distribution function (ECDF)-based statistical distance measures in a designed human-in-the-loop procedure to ensure the safety of machine learning-based classifiers in autonomous vehicle software. The approach is model-agnostic and it can cover various machine learning and deep learning classifiers. The German Traffic Sign Recognition Benchmark (GTSRB) is used to illustrate the capabilities of the proposed approach. / This work was supported by the Secure and Safe MultiRobot Systems (SESAME) H2020 Project under Grant Agreement 101017258.