Class of 2012 Abstract / Specific Aims: To assess the accuracy of the presenting signs and symptoms, diagnostic procedures, and treatments presented in the last twelve episodes of season five of the popular medical drama, House, MD. Methods: A descriptive retrospective evaluation of the accuracy and inaccuracies of episodes 13 to 24 in season five of the television series House, MD. The accuracy of the presenting signs and symptoms, diagnostic procedures, and treatment in each episode was rated on a scale of one to four. A rating of one described a correct and usual representation. A rating of two described a correct but somewhat unusual representation. A rating of three described a correct but extremely unusual representation. A rating of four described an incorrect representation. Each researcher independently rated the episodes, and then a collaborative rating was agreed upon by both researchers. Main Results: Results of the ANOVA test demonstrated a statistically significant difference between the three dependent variables (p=0.002). The Tukey HSD post-hoc test confirmed a significant difference between the accuracy of treatment when compared with signs and symptoms (p=0.012), and with diagnostic procedures (p=0.002). The average rating for the treatment variable was 1.58 (0.9), whereas the average ratings for the signs and symptoms and diagnosis variables were 2.75 ( 0.754), and 3 (1.128), respectively. Conclusions: The treatments presented in the last twelve episode of season five of House, MD were more accurate than both the presenting signs and symptoms and the diagnosis.