Recycled concrete is among the rising eco-friendly construction materials which helps to reduce waste and the need for new natural resources. However, such concrete may present previous deterioration due to, for instance, alkali-silica reaction (ASR), which is an ongoing distress mechanism that may keep being developed in the recycled material. This work aims to evaluate the potential of further distress and crack development (i.e. initiation and propagation) of AAR-affected RCA concrete in recycled mixtures displaying distinct past damage degrees and reactive aggregate types. Therefore, concrete specimens incorporating two highly reactive aggregates (Springhill coarse aggregate and Texas sand) were manufactured in the laboratory and stored in conditions enabling ASR development. The specimens were continuously monitored over time and once they reached marginal (0.05%) and very high (0.30%) expansion levels, they were crushed into RCA particles and re-used to fabricate RCA concrete. The RCA specimens were then placed in the same previous conditions and the “secondary” ASR-induced development monitored over time. Results show that the overall damage in ASR-affected RCA concrete is quite different from affected conventional concrete, especially with regards to the severely damaged RCA particles, where ASR is induced by a reactive coarse aggregate, as the RCA particle itself may present several levels of damage simultaneously caused by past/ongoing ASR and newly formed ASR. Moreover, the influence of the original damage extent in such RCA concrete was captured by the slightly damaged RCA mixture eventually reaching the same damage level as the severely damaged mixture. Furthermore, the original extent of deterioration influence the “secondary” induced expansion and damage of RCA concrete since the higher the original damage level, the higher the cracks numbers and lengths observed in the RCA concrete for the same expansion level whereas wider cracks are generated by RCA having previously been subjected to slight damage thus indicating the difference in the distress mechanism as a function of original extent of damage. In addition, it has been found that distress on RCA containing a reactive sand generates and propagates from the residual mortar (RM) into the new mortar (NM) as opposed to RCA containing a reactive coarse aggregate, being generated and propagated from the original coarse aggregate (i.e. original virgin aggregate – OVA) into the NM. Likewise, RCA containing a reactive sand caused longer and higher number of cracks for the same “secondary” induced expansion than the RCA made of reactive coarse aggregate. Finally, novel qualitative and descriptive models are proposed in this research to explain ASR-induced distress generation and propagation on RCA mixtures made of reactive fine and coarse aggregates.