• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 55
  • 3
  • 2
  • 1
  • 1
  • 1
  • Tagged with
  • 64
  • 17
  • 13
  • 11
  • 8
  • 7
  • 7
  • 6
  • 6
  • 6
  • 5
  • 5
  • 5
  • 5
  • 4
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The synthesis of secretin and the preparation and purification of glucagon analogs for use in the study of hormone-receptor interactions

Wright, David Erick, 1948- January 1976 (has links)
No description available.
2

Characterization of the human secretin receptor gene /

Fong, Shi-ming. January 1998 (has links)
Thesis (M. Phil.)--University of Hong Kong, 1999. / Includes bibliographical references (leaves 68-83).
3

Cloning and characterization of the first amphibian secretins and secretin receptor functional implication of secretin with orexin in amphibians /

Lau, Kwan-wa. January 2009 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2010. / Includes bibliographical references (leaves 131-143). Also available in print.
4

The role of secretin in regulating aldosterone synthase expression in mouse

Tam, Chin-pang, 譚展鵬 January 2014 (has links)
Water and salt homeostasis is tightly controlled by both central and peripheral mechanisms. Angiotensin II (ANGII) and Vasopressin (VP) have long been known to be essential in this regulatory process. Recent studies have found that secretin (SCT) can regulate water homeostasis by playing osmoregulatory functions redundant as ANGII to stimulate VP expression and release in the hypothalamus. However, the functional role of secretin in salt homeostasis, which is closely related to water homeostasis, remains unclear. This study therefore aims to investigate the modulating function of secretin in the synthesis of aldosterone, which is known to be critical in salt regulation. Using immunohistochemical staining, expression of secretin receptor (SCTR) was detected in the zona glumerulosa of adrenal cortex. In mouse adrenal gland, real time quantitative polymerase chain reaction showed that both intraperitoneal (IP) and intracerebral ventricular (ICV) injections of SCT significantly increased aldosterone synthase (cyp11b2) expression levels. This effect was determined to be secretin-specific as it is not observed in SCTR knockout (SCTR-/-) mice. The increase of aldosterone synthase expression levels was further confirmed by Western blot analysis. In circulation, the serum level of aldosterone was also increased by ICV SCT injection, supporting the activation of aldosterone synthase by both central and peripheral SCT. Further studies showed the ICV-SCT induced aldosterone synthase can be significantly reduced by conivaptan, a VP receptor antagonist, indicating that the stimulatory effect of SCT on aldosterone synthesis is VP-related. In low sodium diet-fed mice, both SCTR and aldosterone synthase expression level were significantly increased and elevated serum SCT level was also observed. Western blot analysis also found an increase in aldosterone synthase expression in wild type mice but not in SCTR-/- controls. These results warrant the further study of the role of SCT in sodium retention. In summary, SCT facilitates the synthesis of aldosterone through the up-regulation of aldosterone synthase. This effect can be triggered by both central and peripheral administration of SCT. The central effect of SCT on aldosterone synthesis is vasopressin-related. SCT may also participate in the sodium retention under low-salt conditions. Taken together, this study suggests a potential function of SCT in regulating body sodium homeostasis. / published_or_final_version / Biological Sciences / Master / Master of Philosophy
5

Characterization of the human secretin receptor gene

方士銘, Fong, Shi-ming. January 1998 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
6

Role of N-linked glycosylation on the function and expression of the human secretin receptor /

Pang, Ting-kai, Ronald. January 1998 (has links)
Thesis (M. Phil.)--University of Hong Kong, 1999. / Includes bibliographical references (leaves 59-72).
7

Cloning and characterization of the first amphibian secretins and secretin receptor: functional implication ofsecretin with orexin in amphibians

Lau, Kwan-wa, 劉君華 January 2009 (has links)
published_or_final_version / Biological Sciences / Master / Master of Philosophy
8

The development and characterization of a knockout model for secretin

Siu, Kwan-yin., 蕭君言. January 2008 (has links)
published_or_final_version / Biological Sciences / Doctoral / Doctor of Philosophy
9

Transcriptional regulation of the human secretin receptor gene expression

何寶琪, Ho, Po-ki. January 1999 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
10

Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor /

Chan, Yuen-yee, Kathy, January 2001 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 85-112).

Page generated in 0.1607 seconds