Spelling suggestions: "subject:"ecu'amamienne A"" "subject:"ecu'amamante A""
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Studies directed towards the synthesis of secu'amamine APadilla Acevedo, Angela Isabel 21 February 2014 (has links)
Herein is described our synthetic studies towards the synthesis of secu'amamine A, a member of the Securinega alkaloids. The first chapter describes the isolation, biological significance and previous synthesis of secu'amamine A. Chapter 2 discusses our proposed biogenetic origin of secu'amamine A from allosecurinine and the model studies to support the intermediacy of the putative aziridinium ion. Chapter 3 discusses our synthetic approach to the formation of rings A and C, as well as investigations on the regioselective functionalization of 1,2-dihydropyridines. Chapter 4 discusses the synthesis of ring D from ring D' and the transformations of our advanced intermediates with different carbamate protective groups. Chapter 5 consists of experimental details and characterization data for all new compounds. / text
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