CHDS State/Local / Approved for public release; distribution is unlimited / The concept of biosecurity as it pertains to Biological Select Agents and Toxins in American biomedical research institutions is explored in some depth. Posing the research question "How can specific public biomedical research universities securely use and store biological select agents?" the thesis outlines the dynamics of the select agent and toxin list, the relevant history of the control of biological agents both in the international and domestic settings, including federal regulations pertaining to biosecurity (42CFR73). Two specific case studies are presented in the thesis. The biosecurity strategies and tactics at these two distinct biomedical research are compared. An answer to the research question is proposed and additional areas for research are outlined. / Captain, the University of Texas at Houston Police Department