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The effects of selenium and vitamin E intake on diet-induced oxidative stress and hyperlipidemia /Poirier, Johanne, 1959- January 2000 (has links)
To examine the effects of fat composition and supplemental vitamin E (Vit E) and selenium (Se) on in vivo lipid peroxidation, diet-induced hypercholesterolemia, and glutathione (GSH) metabolism, male Syrian hamsters were fed for three weeks butter fat (BF-) or fish oil- (FO-)based diets supplemented with Vit E and/or Se. The effect of supplemental Vit E and Se on tissue lipid peroxidation (LPO), glutathione peroxidase (GSH-Px) activity and GSH concentrations differed between heart and liver and also was affected by dietary fat. The reduced glutathione/oxidized glutathione (GSH/GSSG) ratio was more consistently associated with tissue lipid peroxidation than was tissue Vit E content. Plasma lipids were lowered with supplemental Se and Vit E. Se supplementation, however, exerted a more potent hypolipidemic effect than Vit E. A pro-oxidative action of Se in hearts of FO-fed hamsters was noted, which was inhibited by supplemental Vit E. Hence, the combination of Vit E and Se may offer the most benefit against diet-induced oxidative stress and hyperlipidemia.
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Effect of dietary fluoride on selenite toxicity in the ratYu, Qing, 1966- 28 January 1992 (has links)
Two factorial experiments were conducted to determine if
high dietary fluoride would inhibit selenite toxicity in
rats. In each study, two levels of selenite (0.05 and 5
mg/kg diet) were matched against two levels of fluoride (1
and 150 mg/kg diet) for either 6 or 8 weeks. Fluoride failed
to prevent the depressive effect of selenite on food intake
and body weight gain in either study. Although liver
selenium concentration was slightly (15%) but significantly
(P < 0.005) reduced when the highest fluoride and selenium
level were combined in the first study, this effect could not
be repeated. These three measures therefore failed to
provide evidence for a fluoride and selenium interaction.
Fluoride, however, prevented hepatic necrosis seen in most of
the selenite-toxic rats. Hepatic lesions seen histologically
in selenite-toxic rats were not observed for either kidney or heart. With regard to a possible mechanism for the fluoride
effect upon selenite liver pathology, fluoride partially
(26%) but significantly (P < 0.025) reduced thiobarbituricreactive
substances (an indicator of peroxidative cell
membrane damage) in selenite-toxic rats, but there was no
fluoride effect on an enzyme system (liver xanthine oxidase)
that potentially could generate an initiator of lipid
peroxidation. In agreement with results of others, fluoride
deposition into bone was inconsistently affected by selenite,
Overall, the protective effect of fluoride on selenite
toxicity appears to be confined to liver pathology. The
exact mechanism for this effect, however, remains unclear. / Graduation date: 1992
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The effect of lead and zinc on selenium poisoning in miceCall, Cynthia Joy 01 August 1975 (has links)
Trace elements, because they are effective in catalytic amounts, must be held in delicate balance with each other as well as with the macronutrients of the diet. Disturbances of these balances result in deficiency and toxicity symptoms. Toxic doses of selenium, lead, and zinc, for example, are known to cause anemia (1, 2, 3, 4) and growth depression (5, 3) in experimental animals.
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The effects of selenium and vitamin E intake on diet-induced oxidative stress and hyperlipidemia /Poirier, Johanne, 1959- January 2000 (has links)
No description available.
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Effects of selenium and vitamin B-6 on growth of chemically- induced transplanted tumors in BALB/c inbred miceMurphy, Stephanie A. 24 July 2012 (has links)
Male weanling inbred, mice were inoculated with fibrosarcoma cells (hindquarter) originally produced by 2-methylcholanthrene. Before inoculation, mice were randomly divided into three groups of 24 and one of 12 (control). After a one week acclimation period, each group was fed a diet containing either suboptimal vitamin B-6, 0.5 mg/kg diet; adequate, 7.0 mg/kg diet; or excess, 100 mg/kg diet. Controls were fed the adequate vitamin. B-6 diet. Twenty-four hours after tumor cell inoculation, a series of sodium selenite injections (0.5 μg/.10 mL) were given to half of each treatment group and all controls. Mice were sacrificed two wk after tumor inoculation. Tumors were excised and weighed. Selenium-treated mice had significantly smaller tumors as compared to untreated mice regardless of vitamin B-6 treatment. The smallest tumors were found in the selenium-treated group maintained on adequate B-6, while the largest tumors were developed by mice on the excess B-6 diet without selenium treatments. All groups had similar blood selenium levels as measured by gas chromatography. Tumor selenium levels, analyzed by atomic absorption, were significantly higher for untreated groups than selenium-treated groups (larger tumor size). The excess and adequate vitamin B-6 selenium-treated groups had significantly lower tumor selenium levels than the adequate vitamin B-6 untreated group. Plasma pyridoxal phosphate (concentrations) determined radiometrically and tumor vitamin B-6 levels determined microbiologically, related directly to dietary treatments. Sodium selenite injections and adequate vitamin B-6 diets reduced the size of fibrosarcomas in BALB/c inbred mice. / Master of Science
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The effect of selenium on the fatty acid profiles of human breast milk in Chinese womenDodge, Marcie L. 25 April 1997 (has links)
Numerous dietary factors have been shown to influence the fatty acid profiles (FAP)
in breast milk from lactating women. However, few studies have evaluated the effect of trace
minerals on milk FAP. Consequently, the purpose of this study was to determine the effect
of selenium status on the FAP in breast milk. Subjects were lactating women from three
different regions in China; Xichang (n=21), an area where selenium intakes are among the
lowest in the world, Beijing (n=20), where there are adequate selenium intakes, and Enshi
(n=19), where selenium intakes are among the highest in the world. Plasma and milk samples
were obtained from women at birth of their baby and within 10 months postpartum and
analyzed for selenium content, glutathione peroxidase (Gpx) activity and FAP. Plasma and
breast milk selenium levels were significantly lower in the Xichang women and significantly
higher in the Enshi women when compared to Beijing women. Despite the fact that the
highest level of plasma selenium was measured in the samples from Enshi, the Gpx activity
was greatest in the samples from Beijing; there was no effect of time of sampling on these
samples. In breast milk, on the other hand, all the samples obtained at birth had similar
activity of Gpx. The samples taken later, however, followed the same trend as plasma with
the samples obtained from the women in Beijing having the highest activity. FAP indicated
a significant difference in the amount of unsaturated fatty acids in both the plasma and milk
for the Beijing women, when compared to the women from Xichang and Enshi. In particular,
there were higher levels of linoleic acid, 18:2(n-6), in the plasma and milk of the women
whose selenium intake was adequate. / Graduation date: 1997
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