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The presented thesis is involved in the biomechanics of phonation. The aim of the thesis is to set a fluid-structure interaction between the vocal folds and air flow when the pressure from lungs reaches the physiological values. In the expected outcome the self-oscillating vocal folds should be observable with characteristics shape-shift from convergent to divergent. In theory part of the thesis is described Anatomy of the vocal tract, physiology of the human phonation, research of computational simulations, experiments and visualisation methods are described in the theory part of the thesis. In the second part, setup of computational simulation with the finite element method is presented. Besides of the fluid-structure interaction the acoustical model is set. Achieved results are presented and compared to the results in literature. Displacements are evaluated from the structural model and pressures, velocities and flow velocities are evaluated from fluid model, so as acoustics results.