The rapid advances in technologies make the explosive growth of multimedia data possible and available to the public. Multimedia data can be defined as data collection, which is composed of various data types and different representations. Due to the fact that multimedia data carries knowledgeable information, it has been widely adopted to different genera, like surveillance event detection, medical abnormality detection, and many others. To fulfil various requirements for different applications, it is important to effectively classify multimedia data into semantic concepts across multiple domains. In this dissertation, a correlation-based multimedia semantic concept detection framework is seamlessly integrated with the deep learning technique. The framework aims to explore implicit and explicit correlations among features and concepts while adopting different Convolutional Neural Network (CNN) architectures accordingly. First, the Feature Correlation Maximum Spanning Tree (FC-MST) is proposed to remove the redundant and irrelevant features based on the correlations between the features and positive concepts. FC-MST identifies the effective features and decides the initial layer's dimension in CNNs. Second, the Negative-based Sampling method is proposed to alleviate the data imbalance issue by keeping only the representative negative instances in the training process. To adjust dierent sizes of training data, the number of iterations for the CNN is determined adaptively and automatically. Finally, an Indirect Association Rule Mining (IARM) approach and a correlation-based re-ranking method are proposed to reveal the implicit relationships from the correlations among concepts, which are further utilized together with the classification scores to enhance the re-ranking process. The framework is evaluated using two benchmark multimedia data sets, TRECVID and NUS-WIDE, which contain large amounts of multimedia data and various semantic concepts.