abstract: Medical images constitute a special class of images that are captured to allow diagnosis of disease, and their "correct" interpretation is vitally important. Because they are not "natural" images, radiologists must be trained to visually interpret them. This training process includes implicit perceptual learning that is gradually acquired over an extended period of exposure to medical images. This dissertation proposes novel computational methods for evaluating and facilitating perceptual training in radiologists. Part 1 of this dissertation proposes an eye-tracking-based metric for measuring the training progress of individual radiologists. Six metrics were identified as potentially useful: time to complete task, fixation count, fixation duration, consciously viewed regions, subconsciously viewed regions, and saccadic length. Part 2 of this dissertation proposes an eye-tracking-based entropy metric for tracking the rise and fall in the interest level of radiologists, as they scan chest radiographs. The results showed that entropy was significantly lower when radiologists were fixating on abnormal regions. Part 3 of this dissertation develops a method that allows extraction of Gabor-based feature vectors from corresponding anatomical regions of "normal" chest radiographs, despite anatomical variations across populations. These feature vectors are then used to develop and compare transductive and inductive computational methods for generating overlay maps that show atypical regions within test radiographs. The results show that the transductive methods produced much better maps than the inductive methods for 20 ground-truthed test radiographs. Part 4 of this dissertation uses an Extended Fuzzy C-Means (EFCM) based instance selection method to reduce the computational cost of transductive methods. The results showed that EFCM substantially reduced the computational cost without a substantial drop in performance. The dissertation then proposes a novel Variance Based Instance Selection (VBIS) method that also reduces the computational cost, but allows for incremental incorporation of new informative radiographs, as they are encountered. Part 5 of this dissertation develops and demonstrates a novel semi-transductive framework that combines the superior performance of transductive methods with the reduced computational cost of inductive methods. The results showed that the semi-transductive approach provided both an effective and efficient framework for detection of atypical regions in chest radiographs. / Dissertation/Thesis / Ph.D. Computer Science 2012