xii, 179 leaves : tables ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.1979) from the Dept. of Psychology, University of Adelaide

xii, 179 leaves : tables ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.1979) from the Dept. of Psychology, University of Adelaide

abstract: Navigation through natural environments requires continuous sensory guidance. In addition to coordinated muscle contractions of the limbs that are controlled by spinal cord, equilibrium, body weight bearing and transfer, and avoidance of obstacles all have to happen while locomotion is in progress and these are controlled by the supraspinal centers. For successful locomotion, animals require visual and somatosensory information. Even though a number of supraspinal centers receive both in varying degrees, processing this information at different levels of the central nervous system, especially their contribution to visuo-motor and sensory-motor integration during locomotion is poorly understood. This dissertation investigates the patterns of neuronal activity in three areas of the forebrain in the cat performing different locomotor tasks to elucidate involvement of these areas in processing of visual and somatosensory information related to locomotion. In three studies, animals performed two contrasting locomotor tasks in each and the neuronal activities were analyzed. In the first study, cats walked in either complete darkness or in an illuminated room while the neuronal activity of the motor cortex was recorded. This study revealed that the neuronal discharge patterns in the motor cortex were significantly different between the two illumination conditions. The mean discharge rates, modulation, and other variables were significantly different in 49% of the neurons. This suggests a contextual correlation between the motor cortical activity and being able to see. In two other studies, the activities of neurons of either the somatosensory cortex (SI) or ventrolateral thalamus (VL) were recorded while cats walked on a flat surface (simple locomotion) or along a horizontal ladder where continuous visual and somatosensory feedback was required (complex locomotion). We found that the activity of all but one SI cells with receptive fields on the sole peaked before the foot touched the ground: predictably. Other cells showed various patterns of modulation, which differed between simple and complex locomotion. We discuss the predictive and reflective functionality of the SI in cyclical sensory-motor events such as locomotion. We found that neuronal discharges in the VL were modulated to the stride cycle resembling patterns observed in the cortex that receives direct inputs from the VL. The modulation was stronger during walking on the ladder revealing VL’s contribution to locomotion-related activity of the cortex during precision stepping. / Dissertation/Thesis / Doctoral Dissertation Neuroscience 2016

Organismos são capazes de diferenciar estímulos sensoriais gerados independentemente pelo ambiente dos estímulos causados por sua própria ação no mundo. Esse processo depende de mecanismos neurais e cognitivos que unam suas ações às percepções por elas geradas. Objetivo desse trabalho foi investigar a interação da ação com a percepção visual no domínio temporal. Em cinco experimentos psicofísicos, foi estudado o efeito modulatório da ação no efeito flash-lag e em tarefas envolvendo estimativas de intervalos temporais. Nossos resultados mostraram que o planejamento e/ou execução de atos motores voluntários são capazes de reduzir em algumas dezenas de milissegundos as latências com que estímulos visuais são percebidos e também de reduzir as estimativas de intervalos temporais. A redução dessas latências é maior quando a conseqüência sensorial da ação é apresentada na fóvea, assim como quando existe um atraso entre a ação e o estímulo por ela causado. / Organisms are able to distinguish between sensory stimuli from the environment and sensory stimuli they cause. This process depends on neural and cognitive mechanisms that link actions to perceptions generated by these actions. This work aimed to investigate the interaction of action and perception in the temporal domain. In five psychophysical experiments, we have assessed the modulation of action in the flash-lag effect and in tasks involving temporal interval estimations. Our results showed that the planning and execution of a voluntary motor action are capable of reducing both visual perceptual latencies and temporal interval estimations. This reduction increases when the sensory consequences of motor actions are presented on the fovea and when a delay is injected between the action and the stimuli caused by it.

Organismos são capazes de diferenciar estímulos sensoriais gerados independentemente pelo ambiente dos estímulos causados por sua própria ação no mundo. Esse processo depende de mecanismos neurais e cognitivos que unam suas ações às percepções por elas geradas. Objetivo desse trabalho foi investigar a interação da ação com a percepção visual no domínio temporal. Em cinco experimentos psicofísicos, foi estudado o efeito modulatório da ação no efeito flash-lag e em tarefas envolvendo estimativas de intervalos temporais. Nossos resultados mostraram que o planejamento e/ou execução de atos motores voluntários são capazes de reduzir em algumas dezenas de milissegundos as latências com que estímulos visuais são percebidos e também de reduzir as estimativas de intervalos temporais. A redução dessas latências é maior quando a conseqüência sensorial da ação é apresentada na fóvea, assim como quando existe um atraso entre a ação e o estímulo por ela causado. / Organisms are able to distinguish between sensory stimuli from the environment and sensory stimuli they cause. This process depends on neural and cognitive mechanisms that link actions to perceptions generated by these actions. This work aimed to investigate the interaction of action and perception in the temporal domain. In five psychophysical experiments, we have assessed the modulation of action in the flash-lag effect and in tasks involving temporal interval estimations. Our results showed that the planning and execution of a voluntary motor action are capable of reducing both visual perceptual latencies and temporal interval estimations. This reduction increases when the sensory consequences of motor actions are presented on the fovea and when a delay is injected between the action and the stimuli caused by it.

Performance of efficient and precise motor output requires proper planning of movement parameters as well as integration of sensory feedback. Peripheral sensory information is projected not only to parietal somatosensory areas but also to cortical motor areas, particularly the supplementary motor area (SMA). These afferent sensory pathways to the frontal cortices are likely involved in the integration of sensory information for assistance in motor program planning and execution. It is not well understood how and where sensory information from the limb contralateral to motor output is modulated, but the SMA is a potential cortical source as it is active both before and during motor output and is particularly involved in movements that require coordination and bilateral upper-limb selection and use. A promising physiological index of sensory inflow to the SMA is the frontal N30 component of the median nerve (MN) somatosensory-evoked potential (SEP), which is generated in the SMA. The SMA has strong connections with ipsilateral areas 2, 5 and secondary somatosensory cortex (S2) as well as ipsilateral primary motor cortex (M1). As such, the SMA proves a fruitful candidate to assess how sensory information is modulated across the upper-limbs during the various stages of motor output. This thesis inquires into how somatosensory information is modulated in both the SMA and primary somatosensory cortical areas (S1) during the planning and execution of a motor output contralateral to sensory input across the upper-limbs, and further, how and what effect ipsilateral primary motor cortex (iM1) has upon modulation of sensory inputs to the SMA.

Performance of efficient and precise motor output requires proper planning of movement parameters as well as integration of sensory feedback. Peripheral sensory information is projected not only to parietal somatosensory areas but also to cortical motor areas, particularly the supplementary motor area (SMA). These afferent sensory pathways to the frontal cortices are likely involved in the integration of sensory information for assistance in motor program planning and execution. It is not well understood how and where sensory information from the limb contralateral to motor output is modulated, but the SMA is a potential cortical source as it is active both before and during motor output and is particularly involved in movements that require coordination and bilateral upper-limb selection and use. A promising physiological index of sensory inflow to the SMA is the frontal N30 component of the median nerve (MN) somatosensory-evoked potential (SEP), which is generated in the SMA. The SMA has strong connections with ipsilateral areas 2, 5 and secondary somatosensory cortex (S2) as well as ipsilateral primary motor cortex (M1). As such, the SMA proves a fruitful candidate to assess how sensory information is modulated across the upper-limbs during the various stages of motor output. This thesis inquires into how somatosensory information is modulated in both the SMA and primary somatosensory cortical areas (S1) during the planning and execution of a motor output contralateral to sensory input across the upper-limbs, and further, how and what effect ipsilateral primary motor cortex (iM1) has upon modulation of sensory inputs to the SMA.