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Functional studies of the human granzyme family of serine proteases /Mahrus, Sami. January 2004 (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2004. / Includes bibliographical references. Also available online.
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Medicao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina / Protease activated receptors (PARs) mediation in gyroxin biological activitySILVA, JOSE A.A. da 09 October 2014 (has links)
Made available in DSpace on 2014-10-09T12:27:17Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T13:59:13Z (GMT). No. of bitstreams: 0 / Tese (Doutoramento) / IPEN/T / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Medicao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina / Protease activated receptors (PARs) mediation in gyroxin biological activitySILVA, JOSE A.A. da 09 October 2014 (has links)
Made available in DSpace on 2014-10-09T12:27:17Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T13:59:13Z (GMT). No. of bitstreams: 0 / A giroxina é uma enzima serinoprotease do veneno da cascavel sul-americana Crotalus durissus terrificus. É uma toxina apenas parcialmente caracterizada e com múltiplas atividades. Atua na coagulação, na diminuição da pressão arterial e induz um comportamento neurotóxico descrito como rolamento em barril. Os mecanismos envolvidos nestas atividades não são conhecidos. Considerando que a giroxina é uma enzima com alto potencial para ser um novo fármaco com aplicações em clínica médica como a trombina, tripsina, ancrod®, batroxobin® e calicreína, é importante determinar como a giroxina atua. As análises em eletroforese em gel de poliacrilamida e dicroísmo circular confirmaram a pureza e integridade da molécula. A administração intravenosa em camundongos comprovou a neurotoxicidade (rolamento em barril). O estudo in vivo com microscopia intravital comprovou que a giroxina induz vasodilatação com participação dos receptores ativados por proteases (PARs), do óxido nítrico e da Na+K+ATPase. A adesão e rolamento de leucócitos indicaram que não possui atividade pró-inflamatória. A giroxina induziu a agregação plaquetária, que foi bloqueada pelos inibidores dos receptores PAR-1 e PAR-4 (SCH 79797 e tcY-NH2, respectivamente). Finalmente, foi demonstrado que a giroxina alterou temporariamente a permeabilidade da barreira hematoencefálica (BHE). Neste estudo foi comprovado que os receptores ativados por proteases e o óxido nítrico são mediadores envolvidos nas atividades biológicas da giroxina. / Tese (Doutoramento) / IPEN/T / Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Role of the Ca2+ / calmodulin-dependent protein kinase II pathway in the cardioprotective effect of estrogenMa, Yan, 馬妍 January 2008 (has links)
published_or_final_version / Physiology / Master / Master of Philosophy
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SIRT1 promotes cell proliferation and prevents cellular senescence through targeting LKB1 in primary porcine aortic endothelial cellsZu, Yi, 祖毅 January 2009 (has links)
published_or_final_version / Pharmacology and Pharmacy / Master / Master of Philosophy
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Regulations and functions of rho-kinases in hepatocellular carcinomaWong, Chak-lui, Carmen., 黃澤蕾. January 2009 (has links)
The Best PhD Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,2008-2009 / published_or_final_version / Pathology / Doctoral / Doctor of Philosophy
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Determining the subcellular localization of a group II p21-activated kinase - PAK6Unknown Date (has links)
p-21-activated kinase 6 (PAK6) is a serine-threonine protein kinase originally identified as an Androgen Receptor (AR) interacting protein. In current study, we determined the subcellular localization of PAK6 through mutational analysis. We have found that the N-terminal CRIB domain is partly responsible for plasma membrane targeting, the region between amino acid residues #292 to #368 is functionally relevant to plasma membrane localization and that amino acid residues #119 through #190 are responsible for nuclear targeting of PAK6, in addition to a stretch of positively charged N-terminal residues (#2-#11) since mutants lacking this sequence mis-localizes to cytoplasm. In junction forming epithelial cells, PAK6 is demonstrated to co-localize with B-catenin at adherens junctions, suggesting that PAK6 is an activation-dependent event and that PAK6 translocates from plasma membrane to the cytoplasm in response activation via the PKA signal pathway. / by Ciny John. / Thesis (M.S.)--Florida Atlantic University, 2012. / Includes bibliography. / Mode of access: World Wide Web. / System requirements: Adobe Reader.
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The mechanisms of serpin misfolding and its inhibitionDevlin, Glyn L. January 2003 (has links)
Abstract not available
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Genetic and biochemical analysis of Victoria blight : identification of AFLP markers and purification and characterization of the oat saspaseCoffeen, Warren C. 16 May 2003 (has links)
Graduation date: 2003
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SIRT1 promotes cell proliferation and prevents cellular senescence through targeting LKB1 in primary porcine aortic endothelial cellsZu, Yi, January 2009 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 79-95). Also available in print.
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