<p>Selective serotonin re-uptake inhibitors (SSRIs) are a new class of antidepressants used mainly for the treatment of depression and other forms of related disorders. There are a number of side effects associated with these drugs which include loss of weight, sexual dysfunction, nervousness and nausea. A fast and reliable detection method such as biosensing for the determination of the SSRIs metabolic profile is therefore essential for the appropriate dosing of these drugs. Biosensors for the determination of the SSRIs biotransformation were prepared with cytochrome P450 (2D6) isoenzyme and poly (anilinonapthalene sulfonic acid) film electrochemically deposited on gold.</p>

<p>Selective serotonin re-uptake inhibitors (SSRIs) are a new class of antidepressants used mainly for the treatment of depression and other forms of related disorders. There are a number of side effects associated with these drugs which include loss of weight, sexual dysfunction, nervousness and nausea. A fast and reliable detection method such as biosensing for the determination of the SSRIs metabolic profile is therefore essential for the appropriate dosing of these drugs. Biosensors for the determination of the SSRIs biotransformation were prepared with cytochrome P450 (2D6) isoenzyme and poly (anilinonapthalene sulfonic acid) film electrochemically deposited on gold.</p>

Magister Scientiae - MSc / Selective serotonin re-uptake inhibitors (SSRIs) are a new class of antidepressants used mainly for the treatment of depression and other forms of related disorders. There are a number of side effects associated with these drugs which include loss of weight, sexual dysfunction, nervousness and nausea. A fast and reliable detection method such as biosensing for the determination of the SSRIs metabolic profile is therefore essential for the appropriate dosing of these drugs. Biosensors for the determination of the SSRIs biotransformation were prepared with cytochrome P450 (2D6) isoenzyme and poly (anilinonapthalene sulfonic acid) film electrochemically deposited on gold. / South Africa

Thesis (Ph. D.)--University of Washington, 2008. / Vita. Includes bibliographical references (leaves 112-130).

Thesis (M.S.)--West Virginia University, 2010. / Title from document title page. Document formatted into pages; contains vi, 69 p. Includes abstract. Includes bibliographical references (p. 30-39).

Thesis (Ph. D.)--University of Chicago, Dept. of Neurobiology, Pharmacology and Physiology, June 2002. / Includes bibliographical references. Also available on the Internet.

Thesis (Ph.D.)--Baylor University, 2006. / Includes bibliographical references (p. 402-414).

M. Comm. / Psychiatrists are medical doctors who have specialised in the field of Psychiatry. Psychiatry is one of the five major fields in medicine, the other fields being Surgery, Obstetrics and Gynaecology, Internal Medicine and Paediatrics. Psychiatrists treat psychiatric disorders by way of diagnosis and invariably the prescription of the appropriate medication. Sixty to seventy percent of the diagnoses made by psychiatrists in private practice involve the so-called mood disorders in which a depressed mood is a common occurence. Depression is mostly treated with anti-depressant medication. (Olfson and Klerman , 1993:572). Accumulating evidence suggests that the use of anti-depressant medications is increasing. Sclar et. al. examined data from the National Ambulatory Medical Care Survey for the period 1990 through 1995. American National estimates of the number of office-based visits resulting in a prescription for or continuation of anti-depressant pharmacotherapy for any purpose escalated from 16 534 268 in 1990 to 28 664 796 in 1995, a 73,4% increase. (Sclar, Robinson, Skaer, Galin.1998:870) .although a Medline search cannot produce more recent figures it is commonly accepted that the most widely prescribed anti-depressants today fall in the class known as the SSRI's which stands for selective serotonin reuptake inhibitors. Use of a SSRI for the treatment of depression increased from 37.1% in 1990 to 64.6% in 1995. The first SSRI medication to become available on the South African market was fluoxetine under the trade name of Prozac in late 1987. (Preskorn, 1996: 18). To date approximately 25 million people have used Prozac worldwide. Prozac and other newer anti-depressants have been the topic of lead articles in national news magazines, best-selling books and widely watched television talk shows.

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.

This study compared auditory behavioral and physiologic measures in normal control subjects and subjects prescribed with a selective serotonin reuptake inhibitor (SSRI) who were yet to take the drug and those currently taking an SSRI. Test measures used were pure tone averages (PTA), acoustic reflex thresholds, uncomfortable loudness levels (UCL), otoacoustic emissions, masking level difference, temporal integration, amplitude resolution, and Beck Depression Inventory-II (BDI-II) scores. Results indicated that there was a significant difference in the amplitude resolution of the unmedicated group when compared to the medicated and the control group. There was also a significant positive correlation between dynamic range (difference between UCL and PTA) and amplitude resolution. The BDI-II revealed a significant difference between the scores of the unmedicated and the control group as well as the medicated and the control group. Although other test measures indicated differences between the groups, the differences were not statistically significant.