Background: Serum estradiol levels decline after menopause and the effect on mental health-related quality of life (MHR-QOL) is unclear. Objective: To determine if there is an association between endogenous serum estradiol levels and MHR-QOL in healthy postmenopausal women. Methods: This cross-sectional study used baseline Canadian data from the Mammary Prevention.3 trial. Serum estradiol was measured with liquid chromatography-tandem mass spectrometry. Outcomes for MHR-QOL were the Medical Outcomes 36-Item Short Form Health Survey (SF-36) Mental Health Inventory-5 (MHI-5), Mental Component Summary (MCS), and the Menopause-Specific Quality of Life Questionnaire (MENQOL)-psychosocial domain. Results: There were no statistically significant associations between estradiol levels and MHR-QOL in univariate analyses (n=455). Multivariable linear regression predicted statistically significant differences in MCS (R2=0.10, P=0.03) and MENQOL-psychosocial domain (R2=0.10, P=0.04), however estradiol was not a significant predictor. Conclusions: This study did not find a statistically significant association between endogenous serum estradiol levels and MHR-QOL in healthy postmenopausal women.

Background: Serum estradiol levels decline after menopause and the effect on mental health-related quality of life (MHR-QOL) is unclear. Objective: To determine if there is an association between endogenous serum estradiol levels and MHR-QOL in healthy postmenopausal women. Methods: This cross-sectional study used baseline Canadian data from the Mammary Prevention.3 trial. Serum estradiol was measured with liquid chromatography-tandem mass spectrometry. Outcomes for MHR-QOL were the Medical Outcomes 36-Item Short Form Health Survey (SF-36) Mental Health Inventory-5 (MHI-5), Mental Component Summary (MCS), and the Menopause-Specific Quality of Life Questionnaire (MENQOL)-psychosocial domain. Results: There were no statistically significant associations between estradiol levels and MHR-QOL in univariate analyses (n=455). Multivariable linear regression predicted statistically significant differences in MCS (R2=0.10, P=0.03) and MENQOL-psychosocial domain (R2=0.10, P=0.04), however estradiol was not a significant predictor. Conclusions: This study did not find a statistically significant association between endogenous serum estradiol levels and MHR-QOL in healthy postmenopausal women.

Thesis (Ph. D.)--University of Missouri-Columbia, 1998. / Typescript. Vita. Includes bibliographical references (leaves 103-110). Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 1998. / Typescript. Vita. Includes bibliographical references (leaves 103-110). Also available on the Internet.