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1	Effects of Exercise on Serum Lactate Dehydrogenase Activity of Catchable-size Hatchery Rainbow Trout, Salmo gairdneri Klar, Gerlad T. 01 May 1973 (has links) Effects of exercise and the relative condition of exercised fish were viii evaluated for two strains of rainbow trout. Circular tanks fitted with a paddle were used to continuously exercise the fish and a stamina tunnel was used to evaluate the condition of exercised trout. Trout were exercised continuously at one fish-length per second and one-half fish length per second. Serum LDH activity in Shephard-of-the-Hills (Missouri) rainbow trout acclimated to 10 C increased two fold during the first four days of exercise. Serum LDH activity returned to control levels by the tenth day of exercise. Serum LDH activity in Shephard-of-the-Hills rainbow trout exercised at one-half length per second did not increase significantly. Serum LDH activity in Fish Lake stock acclimated to 17 C did not increase significantly. Shephard-of-the-Hills and Fish Lake rainbow trout exercised at one length per second were better conditioned to water velocities of two lengths per second than were controls. exercise serum lactate dehydrogenase rainbow trout hatchery Aquaculture and Fisheries Ecology and Evolutionary Biology Environmental Sciences
2	Mechanisms that Jeopardize Skeletal Muscle Perfusion during Surgery Mak, Timothy 05 December 2013 (has links) We assessed potential mechanisms that may jeopardize skeletal muscle perfusion during surgery leading to adverse outcomes including muscle injury and flap hypoxia. In craniotomy patients, we observed an increase in serum lactate and creatine kinase and urine myoglobin; indicative of muscle damage. The early rise in lactate correlated with elevated BMI, suggesting that obesity caused tissue compression and muscle ischemia. In our rodent model, we investigated the effects of flap preparation and phenylephrine on muscle perfusion by assessing microvascular blood flow and tissue PO2. Phenylephrine reduced muscle blood flow by ~20%, yet increased PO2 by ~10% suggestive of decreased O2 metabolism. At baseline, muscle flap blood flow was reduced by ~50% while PO2 was severely reduced ~80% (~5 torr) suggesting that flap perfusion was attenuated and O2 metabolism was increased. Phenylephrine infusion further reduced muscle flap perfusion. These data demonstrate multiple mechanisms by which muscle perfusion is jeopardized during surgery. Muscle Perfusion Phenylephrine Serum Lactate Creatine Kinase Muscle Damage Muscle Flap Neurosurgery Free Tissue Transfer Rhabdomyolysis Craniotomy Rectus Abdominus Muscle Oxygen Body Mass Index Microvascular Blood Flow 0719
3	Mechanisms that Jeopardize Skeletal Muscle Perfusion during Surgery Mak, Timothy 05 December 2013 (has links) We assessed potential mechanisms that may jeopardize skeletal muscle perfusion during surgery leading to adverse outcomes including muscle injury and flap hypoxia. In craniotomy patients, we observed an increase in serum lactate and creatine kinase and urine myoglobin; indicative of muscle damage. The early rise in lactate correlated with elevated BMI, suggesting that obesity caused tissue compression and muscle ischemia. In our rodent model, we investigated the effects of flap preparation and phenylephrine on muscle perfusion by assessing microvascular blood flow and tissue PO2. Phenylephrine reduced muscle blood flow by ~20%, yet increased PO2 by ~10% suggestive of decreased O2 metabolism. At baseline, muscle flap blood flow was reduced by ~50% while PO2 was severely reduced ~80% (~5 torr) suggesting that flap perfusion was attenuated and O2 metabolism was increased. Phenylephrine infusion further reduced muscle flap perfusion. These data demonstrate multiple mechanisms by which muscle perfusion is jeopardized during surgery. Muscle Perfusion Phenylephrine Serum Lactate Creatine Kinase Muscle Damage Muscle Flap Neurosurgery Free Tissue Transfer Rhabdomyolysis Craniotomy Rectus Abdominus Muscle Oxygen Body Mass Index Microvascular Blood Flow 0719

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