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The spleen in sickle cell anaemia during early childhoodRogers, David Watson January 1982 (has links)
In a study of the natural history of homozygous sickle cell (SS) disease 154 of 160 Jamaican children in whom SS genotype had been diagnosed by cord blood haemoglobin electrophoresis were followed to age 1 to 5 years. Seventeen girls and five boys died. Severe bacterial infections and acute splenic sequestration (ASS) were the principal causes of death. The incidence of each of these complications of SS disease was studied in relation to the natural history of splenomegaly and of splenic reticuloendothelial function. Splenomegaly was assessed by physical examination at each clinic visit. 37% SS children had had palpable spleens by age 6 months, 66% by age 12 months, 79% by age 24 months and 85% by age 36 months. Splenic reticuloendothelial function was assessed by estimating the percentage of pitted blood cells (pit count) using differential interference contrast microscopy. Pit counts in 139 control children with normal haeomoglobin genotype AA were always below 9%. Pit counts performed serially in 130 of the SS children (in 46 from birth) rose with age, and were greater than 9% in 23 SS children at age 1 year, 42% at age 2 years and 52% at age 3 years. Radioactive colloid spleen scans showed no splenic uptake of colloid in 11 SS children with palpable spleens and pit counts greater than 9%, confirming impairment of their splenic reticuloendothelial activity.
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The efficacy of hydroxyurea in decreasing transfusion requirements and hospital admission in children with sickle cell diseaseMackinnon, Diane 20 May 2014 (has links)
The burden of sickle cell disease lies in Africa where
resources are limited . Hydroxyurea may be an affordable
treatmentoption for these patients.
Purpose
To asses whether hydroxyurea has any effect in reducing
vaso-occlusive crises, hospitalization and transfusion
requirements in children with homozygous sickle cell
a n a e m i a . To e v a l u a t e t h e t o x i c i t y o f h y d r o x y u r e a .
M e t h o d s
T h i s i s a r e t r o s p e c t i v e , d e s c r i p t i v e s t u d y o f c l i n i c a l
and h a e m a t o l o g i c a l o u t c o m e s i n c h i l d r e n w i t h s i c k l e c e l l
a n a e m i a t r e a t e d w i t h h y d r o x y u r e a .
R e s u 1t s
Ten p a t i e n t s w e r e e v a l u a t e d . H y d r o x y u r e a d e c r e a s e d t h e
r a t e o f v a s o - o c c 1 u s i o n and d e c r e a s e d t h e t r a n s f u s i o n
r e q u i r e m e n t s . The c l i n i c a l and h a e m a t o l o g i c a l b e n e f i t s
w e r e g r e a t e s t when f o e t a l h a e m o b l o b i n was m a x i m a l . T h e r e
was no s h o r t - t e r m t o x i c i t y .
C o n c l u s i o n
H y d r o x y u r e a a m e l i o r a t e s symptoms in sickle cell disease.
On going studies are n e e d e d t o a s s e s s l o n g - t e r m e f f e c t s .
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Impact of carrier screening on pregnant women's knowledge of sickle cell anemiaMoxley, Kristan Michelle. January 2008 (has links)
Thesis (M.S.)--Case Western Reserve University, 2008. / [School of Medicine] Department of Genetics. Includes bibliographical references.
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Positional and functional approaches towards the cloning of a QTL for heterocellular HPFH on chromosome 6q23Stephens, Philip James January 2000 (has links)
No description available.
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Biophysical analysis of receptor mediated erythrocyte adherence in sickle cell anemia : involvement of infection and hemodynamicsSmolinski, Paula A. 12 1900 (has links)
No description available.
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Effects of a classroom-based direct instruction reading intervention for young children with sickle cell disease.Newton, Sandra Claire, January 2004 (has links)
Thesis (M.A.)--University of Toronto, 2004. / Adviser: Thomas Humphries.
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Determination of the variation in the iTRAQ protein profiling technique /Vanarsa, Kamala, January 2008 (has links)
Thesis (M.S.)--University of Texas at Dallas, 2008. / Includes vita. Includes bibliographical references (leaf 22)
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Proteomic modifications of the sickle red blood cell membrane caused by hydroxyurea /Ghatpande, Swati Sudhir, January 2008 (has links)
Thesis (Ph.D.)--University of Texas at Dallas, 2008. / Includes vita. Includes bibliographical references.
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Universal metastability of sickle hemoglobin polymerization /Weng, Weijun. Ferrone, Frank A. January 2008 (has links)
Thesis (Ph.D.)--Drexel University, 2008. / Includes abstract and vita. Includes bibliographical references (leaves 152-157).
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A microrheological study of sickle hemoglobin polymerization /Zakharov, Mikhail N. Ferrone, Frank A. January 2009 (has links)
Thesis (Ph.D.)--Drexel University, 2009. / Includes abstract and vita. Includes bibliographical references (leaves 98-101).
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