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The psychological effects of sickle cell anemia on individuals diagnosed with the disease a research study submitted in partial fulfillment ... /Escote, Norma F. Smith, Gwendolyn D. Walker, Sandra L. January 1975 (has links)
Thesis (M.S.)--University of Michigan, 1975.
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The psychological effects of sickle cell anemia on individuals diagnosed with the disease a research study submitted in partial fulfillment ... /Escote, Norma F. Smith, Gwendolyn D. Walker, Sandra L. January 1975 (has links)
Thesis (M.S.)--University of Michigan, 1975.
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Using Parental Experiences with Sickle Cell Disease Screening and Diagnosis to Guide Health Science Education: A systematic review and integrative qualitative meta-synthesisGriffith, Simone January 2021 (has links)
Sickle cell disease (SCD) is a chronic, lifelong, often debilitating, inherited disorder that can affect every organ system. Affected individuals often experience repetitive pain crises, multiple hospitalizations and a diminished quality of life. Many people at risk for SCD are unaware of their sickle cell carrier status and surprisingly health care providers’ knowledge of SCD is limited. Research literature focuses mainly on management of clinical manifestations of the disease. This systematic review and integrative qualitative meta-synthesis aims to capture parents’ perspectives on the screening process and diagnosis of SCD or sickle cell trait (SCT). Information generated by this review will be helpful in contributing to the development or enhancement of guidelines and protocols in SCD and SCT management for health care providers and health care educators. / Thesis / Master of Science (MSc)
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The importance of amino acid transport for human red blood cellsKiessling, Katrin January 1997 (has links)
No description available.
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Comparing and contrasting different treatment modalities of sickle cell diseaseBattle, Charity Michelle January 2012 (has links)
Thesis (M.A.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / Sickle cell disease (SCD) is an autosomal recessive disorder affecting over 70,000 people in the United States. Following deoxygenation, red blood cells become deformed and appear in the characteristic sickle-shape. This change in protein structure leads to vasa-occlusive episodes, which may result in a variety of clinical manifestation including, but not limited to, painful crisis, stroke, acute chest syndrome, and/or splenic infarct. Due to the diversity of symptoms, management of this disease can be complex.In SCD, some of the treatment modalities involve controlling infections, pain management, fetal hemoglobin stimulation, blood transfusion, hematopoietic stem cell transplant and potentially gene therapy. This paper discusses the risk and benefits of these different treatment modalities. / 2031-01-01
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Novel approaches to diagnosis, prognosis and pathogenesis of sickle cell diseaseGbotosho, Oluwabukola Temitope January 2015 (has links)
No description available.
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Adherence of sickle red cells to human microvascular endothelial cells : a role for plasma, von Willebrand factor, and platelet thrombospondinBrittain, Henri A. 08 1900 (has links)
No description available.
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An Ethical Analysis of The Black Panther Party and The United States Government’s Sickle Cell Anemia InitiativesTudor-Tangeman, Jessie F.E. 08 October 2020 (has links)
No description available.
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The spleen in sickle cell anaemia during early childhoodRogers, David Watson January 1982 (has links)
In a study of the natural history of homozygous sickle cell (SS) disease 154 of 160 Jamaican children in whom SS genotype had been diagnosed by cord blood haemoglobin electrophoresis were followed to age 1 to 5 years. Seventeen girls and five boys died. Severe bacterial infections and acute splenic sequestration (ASS) were the principal causes of death. The incidence of each of these complications of SS disease was studied in relation to the natural history of splenomegaly and of splenic reticuloendothelial function. Splenomegaly was assessed by physical examination at each clinic visit. 37% SS children had had palpable spleens by age 6 months, 66% by age 12 months, 79% by age 24 months and 85% by age 36 months. Splenic reticuloendothelial function was assessed by estimating the percentage of pitted blood cells (pit count) using differential interference contrast microscopy. Pit counts in 139 control children with normal haeomoglobin genotype AA were always below 9%. Pit counts performed serially in 130 of the SS children (in 46 from birth) rose with age, and were greater than 9% in 23 SS children at age 1 year, 42% at age 2 years and 52% at age 3 years. Radioactive colloid spleen scans showed no splenic uptake of colloid in 11 SS children with palpable spleens and pit counts greater than 9%, confirming impairment of their splenic reticuloendothelial activity.
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The efficacy of hydroxyurea in decreasing transfusion requirements and hospital admission in children with sickle cell diseaseMackinnon, Diane 20 May 2014 (has links)
The burden of sickle cell disease lies in Africa where
resources are limited . Hydroxyurea may be an affordable
treatmentoption for these patients.
Purpose
To asses whether hydroxyurea has any effect in reducing
vaso-occlusive crises, hospitalization and transfusion
requirements in children with homozygous sickle cell
a n a e m i a . To e v a l u a t e t h e t o x i c i t y o f h y d r o x y u r e a .
M e t h o d s
T h i s i s a r e t r o s p e c t i v e , d e s c r i p t i v e s t u d y o f c l i n i c a l
and h a e m a t o l o g i c a l o u t c o m e s i n c h i l d r e n w i t h s i c k l e c e l l
a n a e m i a t r e a t e d w i t h h y d r o x y u r e a .
R e s u 1t s
Ten p a t i e n t s w e r e e v a l u a t e d . H y d r o x y u r e a d e c r e a s e d t h e
r a t e o f v a s o - o c c 1 u s i o n and d e c r e a s e d t h e t r a n s f u s i o n
r e q u i r e m e n t s . The c l i n i c a l and h a e m a t o l o g i c a l b e n e f i t s
w e r e g r e a t e s t when f o e t a l h a e m o b l o b i n was m a x i m a l . T h e r e
was no s h o r t - t e r m t o x i c i t y .
C o n c l u s i o n
H y d r o x y u r e a a m e l i o r a t e s symptoms in sickle cell disease.
On going studies are n e e d e d t o a s s e s s l o n g - t e r m e f f e c t s .
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