Thesis (Ph. D.)--Tufts University, 1973. / Submitted to the Dept. of Chemistry. Access restricted to members of the Tufts University community. Also available via the World Wide Web;

Thesis (Ph.D.)--University of Nebraska-Lincoln, 2009. / Title from title screen (site viewed March 2, 2010). PDF text: xii, 86 p. : ill. (some col.) ; 9 Mb. UMI publication number: AAT 3386756. Includes bibliographical references. Also available in microfilm and microfiche formats.

Thesis (M.Sc.)--York University, 2007. Graduate Progamme in Chemistry. / Typescript. Includes bibliographical references. Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR38764

Thesis (Ph.D.) -- McMaster University, 1998. / Includes bibliographical references (leaves 209-217). Also available via World Wide Web.

published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy

Thesis (Ph. D.)--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [162]-168).

Thesis (Ph.D.) -- University of Rhode Island, 2009. / Typescript. Includes bibliographical references (leaves 205-207).

Thesis (Ph. D.)--University of Rhode Island, 2006. / Includes bibliographical references (leaves 167-180).

A major focus of the Leighton group has been the development of efficient, scalable and step-economical reactions towards our goal of expanding the structural variants of medicinally relevant non-aromatic polyketide natural products. Over the last few years the Leighton group has developed a novel mode of strained-silane Lewis acid activation with the use of weakly-coordinating anionic catalysts. Hyper-coordinate silicates with unprecedented levels of reactivity have facilitated previously unattainable late stage complex fragment couplings. A novel method of chiral anion catalyzed nucleophilic addition to α- and β-diketones has been explored. Finally, an operationally straightforward, efficient and direct β-ketoaldehyde allylation methodology will be discussed.

A nucleophilic cleavage reaction of 2,2,5,5,8,8-hexamethyl-2,5,8-trisilanona-3,6-diyne, I, with several bases, occurs rapidly at room temperature in both polar and non-polar solvents. An attack occurs exclusively at the central silicon regardless of the steric requirements of the bases (alkyllithium). The major products from the reaction of I with tert-butyllithium followed by hydrolysis were 2,2,5,5,6,6-hexamethyl-2,5-disilahepta-3-yne, II, and 2,2,5,5-tetramethyl-2,5-disilahexa-3-yne, VI.