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Combined virtual/experimental multicomponent solid forms screening of sildenafil: new salts, cocrystals, and hybrid salt-cocrystalsBarbas, R., Font-Bardia, M., Paradkar, Anant R, Hunter, C.A., Prohens, R. 30 October 2018 (has links)
Yes / New multicomponent solid forms of sildenafil have been discovered
by means of a combined virtual/experimental cocrystal screening. Coformer
selection of candidates was conducted based on an in silico screening method from
a database of more than 2000 organic compounds, and the intensive experimental
screen produced 23 new solid forms. Since the 12 coformers chosen have a
combination of phenol and carboxylic acid groups, a variety of cocrystals, salts, and
hybrid salt-cocrystals were discovered and characterized.
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