The chemical constituents of organic extracts of a Formosan soft coral Sinularia lochmodes (Kolonko) (collected at Ken-Ting in Taiwan) was studied and isolated twelve nature compounds (1¡V12), including seven new compounds, lochmodesolides A¡VE (1¡V5), 4,6-dibromo-(2',5'- dibromophenoxy) anisole (6), 3£],11-dihydroxy-5£],6£]-expoxy-24- methylene-9,11-secocholestan-9-one (7), and five know compounds (8¡V12),(1R*,5R*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5,8-epoxycyclotetradec-12-ene-10,12-carbolactone (8), (1R*, 5S*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5, 8-epoxycyclotetradec-12-ene-10,12-carbolactone (9), norcembrenolide 5 (10), scabrolides A (11), ineleganolide (12). The structures of 1¡V12 were elucidated by spectroscopic evidences (1D NMR, 2DNMR, IR and MS) and chemical method. The stereochemistry of compound 5 was further confirmed by single-crystal X-ray diffraction analyses. Compounds 8 and 9 showed moderate cytotoxicity against KB, Hela, Med, NCI, DLD-1 and Hepa59T/VGH cancer cell lines.

The chemical constituents of organic extracts of the Formosan soft corals Sinularia sp. and Sinularia lochmodes were studied. Investigation on Sinularia sp. has led to the isolation of eight compounds (1-8), including four new compounds, 1£\,3£]-dihydroxy-24S-methylcholesta-5,9-diene (1), 1£\,3£]-dihydroxy-24-methylencholesta-5-ene (2), 1£\,3£]-dihydroxy -24S-methylcholesta-5-ene (3), sinularioperoxide E (4), and four known compounds, 7-isopropenyl-1,4a-dimethyl-decahydro-naphthalen-1-ol (5), £]-dictyopterol (6), N-(4-hydroxyphenethyl)-3-methyldodecanamide (7), (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8). Also, investigation on the chemical constituent of Sinularia lochmodes has led to the isolation of two new compounds, lochmolin A (9) and lochmolin B (10). The structures of 1¡V10 were elucidated by spectroscopic evidences (1D NMR, 2D NMR, IR, and MS). The activity of compounds 2-6 to inhibit the pro-inflammatory iNOS and COX-2 protein expression of LPS-stimulated RAW-264.7 macrophage cells have been estimated.