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Oral antibiotics for methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) in the primary care setting : incidence of treatment failure and its additional economic impactLabreche, Matthew Jude 08 November 2012 (has links)
Our investigation sought to identify the incidence of treatment failure and its associated costs in patients with methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) treated in the primary care setting. Thirteen clinics participated in this multi-site, observational study. Clinicians consented patients and collected clinical information, pictures, and wound swabs; isolates were processed in the principal investigator's laboratory. Treatment failure was defined as the occurrence of one or more of the following within 90 days: (1) change in antibiotic therapy, (2) subsequent need for incision and drainage, (3) SSTI at new site, (4) SSTI at same site, (5) emergency department visit, or (6) hospitalization. Cost estimates were obtained from the Agency for Healthcare Research and Quality (AHRQ) and Centers for Medicare and Medicaid Service's National Average Drug Acquisition Costs (NADAC). Patients were considered to have “moderate or complicated” SSTIs if they had a lesion ≥ 5cm in diameter, diabetes mellitus, or both. Patients not exhibiting these characteristics were classified as having “mild or uncomplicated” infections. Ninety-eight patients were enrolled. Most patients were of Hispanic ethnicity and more than half of all patients had a body mass index (BMI) ≥ 30kg/m2. The most common treatment modality was incision and drainage (I&D) plus antibiotics (57%). Treatment failure occurred in 21% of all patients at a mean additional cost of $1,933.71. Patients with moderate or complicated SSTIs who received I&D experienced significantly more treatment failures compared mild or uncomplicated patients who received I&D (36% vs. 10%; p = 0.04). The additional cost of treatment failure in patients with moderate or complicated SSTIs was nearly twice that of patients with mild or uncomplicated SSTIs ($2,093.40 vs. $1,255.02; p = 1.0). Treatment failure occurred sooner, on average, in the moderate or complicated group compared to the mild or uncomplicated group (11.8 days vs. 38.8 days; p = 0.06). Among patients with MRSA SSTIs treated in the primary care setting, the rate of treatment failure is high (21%) and costs are considerable ($1,933.71). / text
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The Incidence And Epidemiologic Factors Of Community-acquired Methicillin-resistant Staphylococcus Aureus Skin And Soft Tissue IJohnson, Ivonne 01 January 2010 (has links)
Methicillin-resistant Staphylococcus aureus (MRSA) is a serious public health problem nationwide, threatening to develop into an epidemic. Many of these patients are presenting to their primary care clinics with skin and soft tissue infections (SSTIs). The CDC has reported that in 2005, MRSA was responsible for an estimated 94,000 life-threatening infections and 16,650 deaths. The purpose of this study is to estimate the incidence of CA-MRSA within a specific family practice in Florida and to identify epidemiologic factors, classify antibiotic susceptibility patterns, and evaluate patient education in regard to disease management and prevention. This study was a descriptive, epidemiologic, three-year retrospective medical record review of all wound cultured skin and soft tissue infections that presented to a family practice between January 2007 and December 2009. Sixty-two medical records met the inclusion and exclusion criteria for the study. Of these 62 SSTIs, 44 cultures grew one or more bacterial organisms. The incidence of CA-MRSA was 66% (n=29). The mean age of those with CA-MRSA was 40 years old, with a range from 7 to 90 years old. Sixty-two percent (n=18) were male and 38% (n=11) were female; additionally 69% (n=20) lived within a 10 mile radius from the family practice, while 31% (n=9) lived in a surrounding suburb. The most frequent race was Caucasian 83% (n=24), with African American at 10% (n=3) and Hispanics 7% (n=2). Risk factors associated with CA-MRSA was obesity 41% (n=10), diabetes mellitus 24% (n=7), and a previous history of MRSA infection 24% (n=7). Skin and soft tissue infections were diagnosed as either an abscess 62% (n=18), boil 24% (n=7), pustule 10% (n=3), or cellulitis 4% (n=1). CA-MRSA isolates were susceptible to trimethoprim-sulfamethoxazole 100% (n=29), doxycycline 93% (n=27), and rifampin 100% (n=14). Clindamycin susceptibility was 65% (n=15) with resistance at 30% (n=7) and 5% (n=1) intermediate. Both cephalexin and erythromycin were 100% resistant. Documentation in the medical record on wound care was found in 45% (n=13) of the records. The incidence of CA-MRSA SSTI was 66%, which identifies this suburban community at high risk for this bacterial infection. Risk factors associated with CA-MRSA included obesity (BMI > 30), history of previous MRSA infection, and diabetes mellitus. There were no clinical characteristics that helped distinguish MRSA infection from other bacterial SSTIs. Most SSTI were treated with incision and drainage and a susceptible antibiotic. Judicious use of antibiotics not only provides appropriate treatment, but is also critical in prevention of antibiotic resistance. Lastly, patient education in adequate hygiene is essential in preventing the spread of CA-MRSA
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