by Tsu Yun-Huang Stephen. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1992. / Includes bibliographical references (leaves 87-95). / ACKNOWLEDGEMENT --- p.1 / ABSTRACT --- p.2 / INTRODUCTION --- p.4 / Chapter SECTION 1: --- LITERATURE REVIEW --- p.5 / Chapter 1.1 --- Sensory ending in mammalian skin --- p.7 / Chapter 1.2 --- The slowly adapting type I mechanoreceptor --- p.7 / Chapter 1.3 --- The slowly adapting type II mechanoreceptor --- p.8 / Chapter 1.4 --- The role of the Merkel cell --- p.12 / Chapter 1.5 --- Hair cells as an analogy --- p.13 / Chapter 1.6 --- Molecular mechanism of SAI mechanotransduction --- p.14 / Chapter 1.7 --- Calcium influx and transmitter release --- p.17 / Chapter 1.8 --- Calcium homeostasis --- p.17 / Chapter 1.9 --- Substances that affect Calcium influx --- p.18 / Chapter "a," --- Inorganic ions --- p.18 / Chapter "b," --- Neomycin --- p.20 / Chapter "c," --- Verapamil --- p.20 / Chapter "d," --- Bay K8644 --- p.21 / Chapter 1.10 --- Modulators of intracellular calcium stores --- p.21 / Chapter 1.11 --- Caffeine and cAMP --- p.22 / Chapter 1.12 --- The mitochondria and NaN3 --- p.23 / Chapter SECTION 2: --- METHODS --- p.24 / Chapter 2.1 --- The Nerve Skin In Vitro Preparation --- p.25 / Chapter 2.2 --- Synthetic Interstitual Fluid --- p.25 / Chapter 2.3 --- Localised superfusion --- p.26 / Chapter 2.4 --- Nerve Chamber Perfusion --- p.26 / Chapter 2.5 --- Mechanical Stimulation and Experiment Control --- p.29 / Chapter 2.6 --- Data analysis --- p.29 / Chapter SECTION 3: --- RESULTS --- p.32 / Chapter 3.1 --- Viability of the Preparation --- p.33 / Chapter 3.2 --- Effects of Neomycin --- p.38 / Chapter 3.3 --- Effects of Magnesium --- p.47 / Chapter 3.4 --- Effects of Verapamil --- p.52 / Chapter 3.5 --- Effects of Bay-K-8644 --- p.58 / Chapter 3.6 --- Effects of Caffeine --- p.62 / Chapter 3.7 --- Effects of NaN3 --- p.69 / Chapter SECTION 4. --- DISCUSSION AND CONCLUSION / Chapter 4.1 --- Reliability of data obtained from the present in vitro preparation --- p.75 / Chapter 4.2 --- Comparison of the role of calcium in SAI and SA II receptors --- p.76 / Chapter 4.3 --- Synaptic link between Merkel cell and afferent nerve fibre? --- p.83 / Chapter SECTION5. --- REFERENCES --- p.87

Diss. Stockholm : Karol. inst.

Thesis: M.S., Massachusetts Institute of Technology, Department of Mechanical Engineering, 1981 / Includes bibliographical references. / by John Harvey Serocki. / M.S. / M.S. Massachusetts Institute of Technology, Department of Mechanical Engineering