Composite construction is widely used worldwide and is undergoing significant technological development. New Zealand is part of this development, with new beam options incorporating multiple unstiffened web openings and new deck profiles supported by extensive testing. However, one area where relatively little research has been undertaken is in the interaction of the composite slab with the seismic resisting system under lateral loading. In order to provide important new information in this area, a series of full scale beam-column-joint-slab subassemblies were tested at the University of Canterbury. Specimens tested had moment end plate connections and different combinations of deck tray direction, and isolation of the slab from the column. An additional test uses a sliding-hinge type connection to assess the effect of the floor slab in this type of low damage connection. In these tests the lateral capacity of the seismic resisting system was increased by up to 25% due to the presence of the slab in contact with the column. The increase in capacity is 10% greater for decking running in longitudinal direction than in the transverse direction as a result of a more substantial full depth slab bearing on the column. The floor slabs of the subassemblies with the slab cast against the column all showed a higher level of damage than for those with the isolated column and the post ultimate strength degradation of the subassemblies without special detailing was significant. The subassembly with a section of full depth slab surrounding the column also exhibited a higher capacity but with an improved post ultimate strength degradation. All moment end plate subassemblies sustained drifts of up to 5% without significant strength loss. The sliding hinge joint showed little signs of damage under testing to 5% drift. Some inelastic deformation of the connection and beams was noted above 5% drift. Results from both testing and numerical modelling have shown that the current methods used to design these systems are conservative but within 15% of the values observed. Further testing and modelling will be necessary before any meaningful changes can be made to the way in which these systems are designed. Recommendations have been made regarding the placements of shear studs in plastic hinge zones and the provision of slab isolation around beam-column connections.