Narcolepsy is a disabling sleep disorder that is characterized by persistent sleepiness, and cataplexy – an involuntary loss of waking muscle tone. Cataplexy and narcolepsy are caused by the loss of hypocretin containing neurons in the hypothalamus. However, it is hypothesized that dopamine is also involved in sleep and motor control and plays a role in cataplexy. This study investigated how manipulating dopamine affected sleep and cataplexy in narcoleptic mice devoid of hypocretin. We used d-amphetamine to increase endogenous dopamine levels and quinpirole (D2 agonist) to agonize D2 receptor sites. Amphetamine promoted wakefulness while decreasing sleep in wild-type mice, but was less effective in narcoleptic mice. Amphetamine also reduced cataplexy as well as sleep attacks (an indicator of sleepiness) in narcoleptic mice. Quinpirole had no effect on sleep or wakefulness; however, it potently increased cataplexy without affecting sleep attacks in narcoleptic mice.

Narcolepsy is a disabling sleep disorder that is characterized by persistent sleepiness, and cataplexy – an involuntary loss of waking muscle tone. Cataplexy and narcolepsy are caused by the loss of hypocretin containing neurons in the hypothalamus. However, it is hypothesized that dopamine is also involved in sleep and motor control and plays a role in cataplexy. This study investigated how manipulating dopamine affected sleep and cataplexy in narcoleptic mice devoid of hypocretin. We used d-amphetamine to increase endogenous dopamine levels and quinpirole (D2 agonist) to agonize D2 receptor sites. Amphetamine promoted wakefulness while decreasing sleep in wild-type mice, but was less effective in narcoleptic mice. Amphetamine also reduced cataplexy as well as sleep attacks (an indicator of sleepiness) in narcoleptic mice. Quinpirole had no effect on sleep or wakefulness; however, it potently increased cataplexy without affecting sleep attacks in narcoleptic mice.

Cybersecurity has become an increasingly important concern for both military and civilian infrastructure globally. Because of the complexity that comes with wireless networks, adversaries have many means of infiltration and disruption of wireless networks. While there is much research done in defending these networks, understanding the robustness of these networks is tantamount for both designing new networks and examining possible security deficiencies in preexisting networks. This dissertation proposes to examine the robustness of wireless networks on three major fronts: the physical layer, the data-link layer, and the network layer. At the physical layer, denial-of-service jamming attacks are considered, and both additive interference and no interference are modeled in an optimal configuration and five common network topologies. At the data-link layer, data transmission efficacy and denial-of-sleep attacks are considered with the goal of maximizing throughput under a constrained lifetime. At the network layer, valid and anomalous communications are considered with the goal of classifying those anomalous communications apart from valid ones. This dissertation proposes that a thorough analysis of the aforementioned three layers provides valuable insights to robustness on general wireless networks.