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Exploratory analysis of human sleep dataLaxminarayan, Parameshvyas. January 2004 (has links)
Thesis (M.S.)--Worcester Polytechnic Institute. / Keywords: association rule mining; logistic regression; statistical significance of rules; window-based association rule mining; data mining; sleep data. Includes bibliographical references (leaves 166-167).
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The relationship between elevated night-time Glucocorticoid activity and dreaming: a perspective on sleep-dependent memory consolidationTimol, Ridwana January 2017 (has links)
Background. The consolidation of episodic memory is particularly vulnerable to fluctuations in glucocorticoid levels, both during wakefulness and during sleep. Corticosteroid exposure is associated with changes in endogenous glucocorticoid activity, sleep disruption, episodic memory impairment, and reduced hippocampal volume. This dissertation had two primary aims. The first was to explore the relationship between corticosteroid exposure and sleep-dependent memory processes, including dreaming, with special focus on associations between corticosteroid exposure and (a) night-time glucocorticoid activity and (b) sleep organization. The second was to explore the neuroanatomical foundation for these relationships in young adults with asthma. To achieve these aims, I conducted three studies. Methods. Study 1 (N = 68) used a cross-sectional, matched-sample, quasiexperimental design to compare night-time salivary cortisol levels, memory performance preand post-sleep, sleep organization (measured using polysomnography), and dreaming in groups of asthmatics and non-asthmatics with varying degrees of corticosteroid exposure. Study 2 (N = 23) used a double-blind, randomized placebo-control true experimental design to test, in healthy young adults, the effects of a single 25 mg dose of prednisone on the same outcome measures. Study 3 (N = 19) used a quasi-experimental design to compare hippocampal volume of moderate-to-high corticosteroid-exposed asthmatics with that of matched healthy controls. That study also examined the relationship between (a) night-time cortisol levels and hippocampal volume, (b) night-time cortisol levels and declarative memory performance, (c) hippocampal volume and declarative memory performance. All participants were English-speaking university students, aged 18-39 years. Results. Studies 1 and 2 showed that, relative to healthy controls, night-time glucocorticoid activity was elevated and sleep organization was disrupted in corticosteroidexposed individuals. Furthermore, there were significant inverse associations between glucocorticoid activity and (a) the organization of slow wave sleep (SWS) and rapid-eye movement (REM) sleep, (b) performance on both declarative and procedural memory tasks, and (c) the episodic memory content of dreams. There were significant positive associations between (a) the proportions and the organization of SWS and REM sleep and performance on measures of both declarative and procedural memory, and (b) the organization of REM sleep and the episodic content of dreams. Study 3 data analyses detected significantly smaller hippocampal volume in asthmatics relative to controls. Severity of asthma was inversely related to left hippocampal volume, but corticosteroid exposure alone was not. Furthermore, a smaller hippocampus was associated with better memory performance among healthy controls, but not among asthmatics. Conclusions. The association between the organization of SWS and REM sleep and performance on measures of both declarative and procedural memory lends support to the sequential hypothesis of sleep-dependent memory processing. The current findings also suggest that glucocorticoid activity is associated with (a) dream content, (b) the organization of SWS and REM sleep, and (c) post-sleep memory performance after sleep, and that these relationships may intersect. Although asthmatics did not display memory deficits or aberrant dreaming patterns, their hippocampal volume data, patterns of night-time cortisol, and sleep disruptions suggest further investigation is warranted into the implications of subtle HPA-axis dysfunction and consequent atypical brain development on cognitive function and quality of life in asthmatics, whether exposed to corticosteroid treatment or otherwise.
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A center for sleep research at Emory University HospitalTanner, Brian Charles 08 1900 (has links)
No description available.
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The effect of an a2d calcium channel blocker on sleep parameters in women with chronic primary insomnia: a pragmatic studyEbrahim, Naseem 03 July 2014 (has links)
Chronic neuropathic pain, epilepsy, depression and anxiety disorders have been
treated successfully with pregabalin. Normal subjects, epileptics and patients with
neuropathic pain to whom pregabalin was prescribed showed an improvement in
objective and subjective sleep parameters. To determine if pregabalin’s sleep
enhancing effect is an independent process, it is necessary to test pregabalin in
primary insomniacs who do not have conditions that could be treated by
pregabalin. My study was designed as a double blind, randomised, crossover,
placebo controlled trial, with 50 milligrams of pregabalin or placebo was
administered for eight consecutive nights. I performed polysomnographic
recordings on eight female chronic primary insomniacs on five nights. Sleep
recordings were performed prior to the intervention, and on the first night and
eighth night of each treatment. Subjects filled out subjective scales at baseline and
night eight of every treatment. While polysomnography and subjective scales
showed that my subjects were insomniac, sleep variables during the pregabalin or
placebo period were unchanged when compared to baseline. A daily dose of 50
mg pregabalin did not have any significant effects on either sleep architecture or
subjective sleep variables in female chronic primary insomniacs.
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Health-related quality of life and sleep disorders in Taiwanese people with heart failureChen, Hsing-Mei 28 August 2008 (has links)
Not available / text
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Health-related quality of life and sleep disorders in Taiwanese people with heart failureChen, Hsing-Mei, 1968- 18 August 2011 (has links)
Not available / text
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Sleep disordered breathing in children : neurocognitive and behavioural consequences and the association with increasing body massKohler, Mark January 2008 (has links)
Over the last decade a substantial body of research has focused on the consequences of sleep disordered breathing (SDB) in children. This dissertation presents the results of two large laboratory-based studies.
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A description of sleep patterns and sleep hygiene practices for adults in cardiac rehabilitation programs in Southern MontanaBarker, Tina Marie. January 2009 (has links) (PDF)
Thesis (M Nursing)--Montana State University--Bozeman, 2009. / Typescript. Chairperson, Graduate Committee: Rita E. Cheek. Includes bibliographical references (leaves 47-55).
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Sleep disturbances in gastric cancer patients and their family caregivers /Cho, Maria H. January 2004 (has links)
Thesis (Ph.D.)--University of California, San Francisco, 2004. / Bibliography: leaves 138-166. Also available online.
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Alleviating chronic sleep debt in early adolescence can a school based intervention make a difference? /Richardson, Barbara B. January 2010 (has links) (PDF)
Thesis (Ph. D.)--Washington State University, May 2010. / Title from PDF title page (viewed on June 11, 2010). "College of Nursing." Includes bibliographical references (p. 70-83).
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