The solid phase combinatorial method is an excellent tool for the modulation of protein-protein interactions through focused library generations. Nucleophilic aromatic substitution reactions with an iodinated template on solid phase has opened a door for easy and pure libraries of 13-22 membered medium and macrocyclic peptidomimetics. These peptide mimics showed promising activities for tyrosine kinase receptors. Iodine functionality can then be used to modify the products, on the resin, via Sonogashira and Suzuki couplings and presumably through other organometallic catalysis. The coupled products can have conformational biases that differ from the iodinated macrocycles. These coupling reactions also provide a means to introduce additional pharmacophores and to adjust the solubilities of the products. The fluorinated template also gave libraries of cyclic peptidomimetics on solid phase in good yields and purities. These libraries have improved water solubility over the iodinated libraries. The 3-fluorinated template yielded better results than the 5- fluorinated template. Some compounds showed biological activities in cell survival assays providing strong support of our approach to mimic external β-turn sequences in target proteins. Intrasite dimerization with 1,5-hexadiyne gave a homodimer as a byproduct. Solidphase synthesis of bivalent turn mimics with fluorescent tags has been demonstrated. The key feature of this synthetic route is that homo- and hetero-dimers can be formed chemoselectively from unprotected monomeric precursors. The dimerization reaction is very mild and versatile, as only potassium carbonate is required to affect the coupling. Solution phase library synthesis of small molecule mimics is presented. Some monomers of full sequence mimics have been prepared to afford dimer generations. Theses monomers were combined with linker handles to afford diverse length of dimers. Final combination of monomers to make bivalent compounds is in progress.

Using the characteristics of small-business firms and of their owners, the information from both the joint credit information center and loan auditors, and logistic models, this study analyzes the determinants of the approval of small-business loans made by credit officers. The study also examines whether these determinants are significant in the logistic models of loan default and provide suggestions to credit officers for approving small-business loans. The main findings of this study are as follows. 1. Some specific proxy variables for the characteristics of small-business firms and of their owners and information from both the joint credit information center and loan auditors are significant determinants in the logistic models of loan approval. Their importance or significance will differ when the sample loans are categorized on the basis of sales. 2. The significant determinants in the logistic models of loan default are also significant determinants in the logistic models of loan approval. The result indicates that credit officers are able to effectively consider some factors contributing to loan default when they make loan decisions. Thus, the credit officers perform well in managing credit risk when approving loans. 3. The number of significant determinants in the logistic models of loan approval is far greater than that in the models of loan default. The finding implies that credit officers may place more stringent criteria in approving loans and lose some profitable business opportunities. 4. Establishing different criteria on the basis of sales when approving loans can facilitate the increase in the rate of loan approval and decrease in the rate of loan default. 5. The information from loan auditors plays an important role in the approval of loans to firms with small sales. It seems not to be the case in the approval of loans to firms with large sales. Therefore, it is better that loan auditors be equipped with abundant knowledge of various industrial sectors and be given well on-job training. Moreover, the performance of loan auditors should be independent with the number or size of loans.

Project (M.P.P.) - Simon Fraser University, 2006. / Theses (Master of Public Policy Program) / Simon Fraser University. Also issued in digital format and available on the World Wide Web.

Thesis (Ph. D.)--Open University. BLDSC no. DX223839.

Thesis (M.A.)--Ohio State University. / Bibliography: leaves 88-89. Available online via OhioLINK's ETD Center.

Thesis (Ph. D.)--University of Chicago, Dept. of Education, 2001. / Includes bibliographical references. Also available on the Internet.

Includes thesis t.p. / Originally presented as the author's thesis, Cologne, 1975. Vita. Includes bibliographical references (p. 193-224) and index.

Thesis (D. Min.)--Southwestern Baptist Theological Seminary, 2002. / Includes bibliographical references (leaves 186-203).

This thesis examines the extent to which the Flexible Specialisation model of Industrial organisation constitutes a v Iab Ie and app IIcab Ie strategy for sma II sea Ie manufactur Ing firms In Greece. This Involves: 1. The evaluation of the Flexible Specialisation paradigm as a response and as a way out of the crisis. 2. The analysis of the development trajectory of small scale Industry In Greece. 3. The Identification of the current characteristics of sma II manufacturing firms In Greece, their strengths and their weaknesses. 4. The evaluation of the future prospects of smal I scale Industry In the light of the Flexible Specialisation strategy. The first part of the thesis (chapters 1, 2 and 3) deals wit h the Que st Ion 0f res truc turi ngin v Iew 0f the cri sis and exam Ines a Iternat Ive ways of organ Ising product Ion. It looks more closely to the Flexible Specialisation In the light of academic experimentation with new concepts, ranging from post- Fordlsm to Flexible Accumulation. It evaluates the strengths and the weaknesses of the Flexible Specialisation model, and considers Its merits against previous sma II scale Industry theorisations. The second part of the thesis (chapters 4,5 and 6) exam Ines the po IIt Ica I economy of Industry In Greece In order to unravel the economic, soclo-polltlcal and Institutional factors account Ing for the emergence, conso IIdat Ion and perSistence of small firms as a considerable part of the Greek manufacturing structure. The third part of the thesis (chapters 7, 8 and 9) Is based on evidence from fieldwork material on three manufacturing branches (metalworking-engineering, clothing and plastic products) and brings out similarities and differences of alternative responses to the economic recession. It examines the extent to which flexible specialisation principles have been Introduced by some sma II firms In the sectors under consideration. Finally, the fourth part (chapters 10 and 11) brings together the main themes developed In the course of the thesis In order to explore the scope and deslrabl Ilty of pol Icy InterventIon In the dIrectIon of Inducing a flexIble specialIsatIon restructuring pattern. The major conclusions of the thesIs are summarIsed In the fInal chapter.

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